MON-173 Vitamin D And Glycemic Control In Type 2 Diabetes

Vitamin D has many extra skeletal effects, of which glucose homeostasis has attracted considerable interest, with lower levels reported in certain diabetic groups. The aim of this study was to determine the frequency of Vitamin D deficiency and its effect on glycaemic control in patients with type 2 diabetes mellitus. Methods: A cross-sectional study was conducted in the outpatient department over a period of 6 months comprising 191 patients using non -probability consecutive sampling. After taking informed consent, blood samples for the assessment of Vitamin D levels were obtained from the patients fulfilling inclusion criteria of the study and glycemic control was determined using HbA1c was measured by high-performance liquid chromatography. Results: A significant number of patients with type 2 diabetes mellitus were classed as vitamin D deficient. The frequency of vitamin D deficiency was found to be 69.1% in patients with type 2 diabetes mellitus. Ninety-eight patients (62.4%) who had HbA1c < 8% were found to be vitamin D deficient while 34(100%) patients having HbA1c >8% showed vitamin D deficiency. Patients with vitamin D deficiency were significantly more likely to have poor glycemic control compared to those with adequate levels of vitamin D after multivariate adjustment(p<0.001). Conclusion: Vitamin D levels were low in our cohort of patients with type 2 diabetes mellitus, with deficiency being independently and significantly related to poor glycemic control. In the view of this, we recommend early replacement of vitamin D in patients with Type 2 diabetes mellitus along with the specific therapy to improve the outcome as it may alter the natural history of this disease.