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Structural basis of phosphatidylcholine recognition by the C2–domain of cytosolic phospholipase A(2)α

Ca(2+)-stimulated translocation of cytosolic phospholipase A(2)α (cPLA(2)α) to the Golgi induces arachidonic acid production, the rate-limiting step in pro-inflammatory eicosanoid synthesis. Structural insights into the cPLA(2)α preference for phosphatidylcholine (PC)-enriched membranes have remaine...

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Detalles Bibliográficos
Autores principales:	Hirano, Yoshinori, Gao, Yong-Guang, Stephenson, Daniel J, Vu, Ngoc T, Malinina, Lucy, Simanshu, Dhirendra K, Chalfant, Charles E, Patel, Dinshaw J, Brown, Rhoderick E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550875/ https://www.ncbi.nlm.nih.gov/pubmed/31050338 http://dx.doi.org/10.7554/eLife.44760

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