MON-156 Association of Adhesion Molecule with Diabetes, Diabetic Retinopathy, and Diabetic Kidney Disease

Diabetic retinopathy (DR) and Diabetic Kidney Diseases (DKD) are the common microvascular complication of diabetes and are responsible for the major cause of blindness and end-stage kidney disease worldwide. Variation in the level of cell adhesion molecules is an indicator of the pathogenesis of diabetes and its complications. We hypothesized that a significant difference in cell adhesion molecules (ICAM 1, VCAM 1, ESEL, PSEL and LSEL) in diabetic subjects which can help in prediction and progression of DR and DKD. To examine the association of cell adhesion molecules in diabetes, DR and DKD a cross-sectional study was conducted on a total of 467 type 2 diabetes (T2D) subjects with a duration of diabetes ≥10 years and age ≥ 35 years. The subjects were divided into four groups. The first group is T2D patients with DR (n=62); the second group is T2D patients with DKD (n=113) and the third group is T2D with both DR and DKD (n=154) and group four is T2D patients without DR and DKD as control (n=138). Serum cell adhesion molecules (ICAM 1, VCAM 1, ESEL, PSEL and LSEL) were assessed by biochip immunoassay. The mean age of participants was 54.64 ± 6.11 years. A total of 46.3% of T2D patients were having retinopathy and 57.7% were diagnosed with both DR and DKD. There was a significant difference between the cell adhesion molecules in DR and DKD groups. The cell adhesion molecules also showed significant correlation with common risk factors of DR and DKD. The higher level of cell adhesion molecules in DR and DKD is useful to identify the development and progression of diabetic complications. Thus, early identification can prevent the development of further complication through better management.