MON-216 Sexual Dysfunction and Eating and Sleeping Disorders in Women with PCOS: A Systematic Review and Meta-Analysis

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting up to 10% of women in the reproductive age. Prior studies indicate PCOS can be associated with increased risk of eating and sleep disorders. Methods: A comprehensive search including MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus through August 01, 2018 was conducted for studies reporting the prevalence of any eating or sleep disorders in patients with PCOS. Independent reviewers selected studies and extracted data. A random-effects model was utilized to generate pooled odds ratios (OR) and 95% confidence intervals (CI) for binary outcomes, and mean difference (MD) and 95% CI for continuous outcomes. Results: We included 36 studies with 349,529 patients. Compared to women without PCOS, women with PCOS were more likely to have bulimia nervosa (OR 1.37; %CI, 1.17 to 1.60), binge eating (OR 2.95; 95%CI, 1.61 to 5.42), or any eating disorder (OR 1.96; 95% CI 1.18 to 3.24); but not anorexia nervosa (OR 0.92; 95%CI, 0.78 to 1.10). Women with PCOS were more likely to have sleep disorders such as hypersomnia (OR 4.39; %CI, 1.07 to 18.07) and obstructive sleep apnea (OR 10.81; %CI, 2.39 to 48.83). Women with PCOS had lower sexual satisfaction when assessed with a visual analogue scale of 0-100 (MD -29.67; 95% CI, -36.97 to -22.37) but no difference in Total Female Sexual Function Index (FSFI) scale of 0-36 (MD -0.06; 95% CI, -0.51 to 0.38). Conclusion: PCOS can be associated with an increased risk of eating, sleep and sexual satisfaction disorders. Timely screening for these disorders may allow appropriate intervention and mitigation of long term morbidity.