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MON-537 Fusion of Parathyroid Hormone to Growth Hormone Binding Protein Delays Clearance Whilst Retaining Biological Activity

Parathyroid hormone (PTH) is an 84 aa peptide and biological activity resides in residues 1-34. PTH 1-84 (Natpara) is licensed for treatment of hypoparathyroidism replacement but requires daily injections and is complicated by fluctuating calcium levels. There is an unmet need for a long acting PTH...

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Detalles Bibliográficos
Autores principales:	Wilkinson, Ian, Eastell, Richard, O'Regan, Alice, Ross, Richard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Endocrine Society 2019
Materias:	Bone and Mineral Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550917/ http://dx.doi.org/10.1210/js.2019-MON-537

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