MON-337 A Case Study: Steroid and Gonadotropin Hormones Secretion Pattern in Ovarian Cancer: 10-Year Follow-Up

Background: The ovaries in females maintain the health of the reproductive system. The ovaries secrete two main hormones, estrogen and progesterone. In ovarian cancer (Granulosa cell tumor) the secretion pattern of these hormones changes and few data are available that clearly describes the secretion of these hormones. Clinical case: In may 2007, in Port Harcourt, Rivers State, South of Nigeria, a 46years old woman was diagnosed with tumor of the ovaries (Granulosa cell tumor)), stage 11 after presenting features of ovarian cancer, that includes infertility and 9 months secondary amenorrhea The study investigated the sex hormones and gonadotropin hormones secretion pattern before the surgery and post surgery chemotherapeutic treatment for about 10years. Because of her interest in still getting pregnant, she resisted the surgery for about six months. Within this period the samples were collected thrice for the sex hormones (estrogen, progesterone, and testosterone), Inhibin B and gonadotropic hormones (FSH and LH). After Salpingo-oophorectomy was performed, the samples for the hormones were thereafter collected twice every year till August 2017 when she died at the age of 57years. Enzyme Linked Immunosorbent Assay (ELISA) method was used for the determination of the hormones. The result showed a Mean S.D serum estradiol level of 386.55 35.62 pg/ml, progesterone level of 3.26 0.44ng/ml, testosterone level of 0.62 0.24 ng/ml, Inhibin B = 145.90 20.05 pg/ml. The serum FSH was 1.95 0.84miu/ml, LH = 4.07 1.55 miu/l at preoperatomy. 3 months after the surgery, the sex hormones reduced significantly (P<0.05) by about 92.1%, the serum inhibin B reduced to 34.7pg/ml and the FSH increased by about 23.50% with no statistical difference in the values for LH, with a value of 2.97 miu/ml. The sex hormones secretion increased by 9.34% by the 8(th) to the 10(th) year before her death without any significant change in the gonadotropic hormones. The origin of the slight increase in the sex hormones secretion is unclear, but should be attributed to its secretion from other sources (Fat cells and adrenal) apart from the ovary. Conclusion: The hormone studies in a case of granulosa cell tumor of the ovary was established pre-and postoperatively. The sex hormones were elevated and gonadotropic hormones reduced significantly before surgery. Postoperative sex hormones secretion showed undetected levels, the slight increase in the sex hormone levels after about 6 years postoperative were not statistically significant (P>0.05).