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MON-538 Ca(2+)Allostery in PTH-Receptor Signaling

The parathyroid hormone (PTH) type 1 receptor (PTHR) serves as the cognate receptor for two endogenous ligands, PTH and its related peptide (PTHrP). Binding of PTHrP to the PTHR results in only transient cAMP production that is limited to the plasma membrane, while PTH induces sustained cAMP respons...

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Detalles Bibliográficos
Autores principales:	White, Alex, Sutkeviciute, Ieva, Jean-Alphonse, Frederic, Xiao, Kunhong, Vilardaga, Jean-Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Endocrine Society 2019
Materias:	Bone and Mineral Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551044/ http://dx.doi.org/10.1210/js.2019-MON-538

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