MON-626 Survey of Thyroid Antibody Positivity and Treated Hashimoto’s Disease in Nodular Thyroid Disorders

The prevalences of anti-thyroid antibodies and treated Hashimoto’s disease (t-HD) are reported to be higher than in the general population in Papillary cancer and Benign Lymphocytic nodules. This survey was conducted to establish if other thyroid nodular diseases exhibit the same or other patterns of antibody positivity or treated Hashimoto’s disease. Antibody Positivity was regarded as an elevation of Anti-Peroxidase antibodies (Anti-P) and/or Anti-Thyroglobulin antibodies (Anti-T). For reference purposes, the 1988-1994 National Health and Nutrition Examination Survey (NHANES III) determined that Anti-P and Anti-T positivities were elevated in 11.3% and 10.4%, respectively, in a thyroid disease-free U.S. population. The prevalence of Hashimoto’s disease in the U.S. has been estimated at 0.2-2%. The database consisted of 310 nodules diagnosed by fine needle aspiration (FNA) and/or surgical pathology (Surg). For each subset of nodule type the sequence of numbers represents the sample number, the % Anti-P, the % Anti-T, and the % t-HD: Nodular Goiter (FNA) 69, 16.3%, 6.0%, 3.0%; Benign Follicular Cells (FNA) 43, 31.0%, 12.9%, 11.6%; Colloid Nodules (FNA) 53, 20.5%, 22.0%, 7.7%; Benign Lymphocytic Nodules (FNA) 13, 100.0%, 100.0%, 69.2%; Adenomatous Nodules (FNA) 15, 0.0%, 0.0%, 0.0%; Adenomatous Nodules (Surg) 6, 0.0%, 0.0%, 0.0%; Follicular Neoplasms (FNA) 23, 33.3%, 19.0%, 26.1%; Follicular Adenomas (Surg) 7, 33.3%, 0.0%, 28.6%; Follicular Cancer (Surg) 8, 28.6%, 0.0%, 12.5%; Suspicious for Papillary Cancer (FNA) 19, 23.5%, 11.1%, 5.3%; Papillary Cancer (FNA) 13, 22.2%, 10.0%, 0.0%; Papillary Cancer (Surg) 41, 23.1%, 21.9%, 12.8%. Major observations: with the exception of Adenomatous nodules, the % Anti-P in all types of nodules was greater than in the general population. The % Anti-T was unexpectedly low for Nodular Goiters, Adenomatous (Hyperplastic) nodules and Follicular Cancers although the sample numbers for the latter two subsets were small. With the exception of and Adenomatous Nodules the % of Treated Hashimoto’s disease was clearly higher than in the general population. Only 9 patients exhibited Anti-T positivity and Anti-P negativity, a pattern thought not to be associated with thyroid disease in the NHANES III survey.