MON-016 Maternal Hyperuricemia Superimposed on Maternal Hypertension Aggravates the Risk of Small-for-Gestational-Age Fetus

Purpose: Small-for-gestational-age (SGA) fetus is an important public health issue because of its high mortality and long-term effects on health. Maternal hyperuricemia is associated with diverse adverse pregnant outcomes and neonatal disturbance. We aimed to evaluate whether maternal hyper-uric acid (HUA) is associated with the risk of SGA fetus and to explore whether it can modify the association between maternal hyper-blood pressure (HBP) and fetal SGA. Methods: We performed a population-based cross-section retrospective study, a total of 7,061 pregnant females were recruited. Multiple logistic regression analysis was performed to identify risk factors significantly correlated with fetal SGA, and then studied the effect of maternal HUA (>374.72 µmol/L, William's obstetrics) on the association between maternal HBP and fetal SGA. Results: We collected 576 SGA fetuses among 7,061 pregnant females. Maternal HUA was an independent risk factor for SGA delivery (odds ratio (OR), 2.260; 95% confidence interval (CI), 1.748-2.921). A dose-response association between maternal uric acid and SGA delivery was found among normotensive and hypertensive group, especially significantly in latter group. Compared with those whose uric acid was lower than 320μmo/L with normal-blood pressure (NBP), the risk for SGA delivery in those whose uric acid was higher than 370μmo/L with stage 2 or 3 hypertension increased 9.429-fold. Conclusions: Our results suggest that maternal HUA could increase the risk of neonatal SGA, and maternal HUA could be superimposed upon pre-existing maternal HBP and increase the risk for fetal SGA.Keywords: Maternal; Uric acid; Hypertension; Fetal; Small for gestational age Source of research report: National Natural Science Foundation of China (81471078, 81770860 and 81641030) and Key Research and Development Plan of Shandong Province, 2016GSF201007.