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MON-459 ONO-5788, a Novel Oral Small Molecule Somatostatin Receptor Type-2 (SST2) Agonist, Attenuates GH Hypersecretion in Human GH-Secreting, Pituitary Adenoma-Derived Cells

Somatostatin receptor ligands (SRL) and GHR antagonists are used for persistent or recurrent acromegaly following noncurative surgery and as primary therapy for patients unsuitable for surgery. We tested in vitro action of a novel oral SRL compound ONO-5788 and its active metabolite (ONO-ST1-641) wh...

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Detalles Bibliográficos
Autores principales:	Zhou, Cuiqi, Bonert, Vivien, Mamelak, Adam, Kelly, Daniel, Barkhoudarian, Garni, Hoon, Dave, Komagata, Tatsuya, Shinozaki, Koji, Melmed, Shlomo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Endocrine Society 2019
Materias:	Neuroendocrinology and Pituitary
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551177/ http://dx.doi.org/10.1210/js.2019-MON-459

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