Cargando…
The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype
Cellular senescence is a stress response program characterized by a robust cell cycle arrest and the induction of a proinflammatory senescence-associated secretory phenotype (SASP) that is triggered through an unknown mechanism. Here, we show that, during oncogene-induced senescence (OIS), the Toll-...
Autores principales: | Hari, Priya, Millar, Fraser R., Tarrats, Nuria, Birch, Jodie, Quintanilla, Andrea, Rink, Curtis J., Fernández-Duran, Irene, Muir, Morwenna, Finch, Andrew J., Brunton, Valerie G., Passos, João F., Morton, Jennifer P., Boulter, Luke, Acosta, Juan Carlos |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551188/ https://www.ncbi.nlm.nih.gov/pubmed/31183403 http://dx.doi.org/10.1126/sciadv.aaw0254 |
Ejemplares similares
-
Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence
por: Fernández-Duran, Irene, et al.
Publicado: (2021) -
Inhibition of the 60S ribosome biogenesis GTPase LSG1 causes endoplasmic reticular disruption and cellular senescence
por: Pantazi, Asimina, et al.
Publicado: (2019) -
Toll-like receptor 2 orchestrates a tumor suppressor response in non-small cell lung cancer
por: Millar, Fraser R., et al.
Publicado: (2022) -
Notch Signaling Mediates Secondary Senescence
por: Teo, Yee Voan, et al.
Publicado: (2019) -
Paracrine cellular senescence exacerbates biliary injury and impairs regeneration
por: Ferreira-Gonzalez, Sofia, et al.
Publicado: (2018)