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High-throughput mapping of CoA metabolites by SAMDI-MS to optimize the cell-free biosynthesis of HMG-CoA

Metabolic engineering uses enzymes to produce small molecules with industrial, pharmaceutical, and energy applications. However, efforts to optimize enzymatic pathways for commercial production are limited by the throughput of assays for quantifying metabolic intermediates and end products. We devel...

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Detalles Bibliográficos
Autores principales:	O’Kane, Patrick T., Dudley, Quentin M., McMillan, Aislinn K., Jewett, Michael C., Mrksich, Milan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551189/ https://www.ncbi.nlm.nih.gov/pubmed/31183410 http://dx.doi.org/10.1126/sciadv.aaw9180

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