Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease

Positive transcription elongation factor b (P-TEFb) functions as a central regulator of transcription elongation. Activation of P-TEFb occurs through its dissociation from the transcriptionally inactive P-TEFb/HEXIM1/7SK snRNP complex. However, the mechanisms of signal-regulated P-TEFb activation an...

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Detalles Bibliográficos
Autores principales: Sun, Yongzhan, Liu, Zhiheng, Cao, Xinyi, Lu, Yi, Mi, Zeyun, He, Chaoran, Liu, Jing, Zheng, Zhanye, Li, Mulin Jun, Li, Tiegang, Xu, Dechao, Wu, Ming, Cao, Ying, Li, Yuhao, Yang, Baoxue, Mei, Changlin, Zhang, Lirong, Chen, Yupeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551191/
https://www.ncbi.nlm.nih.gov/pubmed/31183407
http://dx.doi.org/10.1126/sciadv.aaw3593

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