A Digestion-free Method for Quantification of Residual Host Cell DNA in rAAV Gene Therapy Products

Recombinant adeno-associated virus (rAAV) is a vector with increasing popularity in the field of gene therapy. Like other drug substances manufactured in cell lines, rAAV vectors are commonly contaminated with host cell DNA, and the levels must be carefully monitored. The current method for residual...

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Detalles Bibliográficos
Autores principales: Wang, Yu, Cooper, Rebecca, Kiladjian, Albert, Bergelson, Svetlana, Feschenko, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551374/
https://www.ncbi.nlm.nih.gov/pubmed/31194094
http://dx.doi.org/10.1016/j.omtm.2019.05.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551374/
https://www.ncbi.nlm.nih.gov/pubmed/31194094
http://dx.doi.org/10.1016/j.omtm.2019.05.005

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