Neutrophil-to-lymphocyte ratio (NLR) fails to predict outcome of diffuse large B cell lymphoma

BACKGROUND: Neutrophil-to-lymphocyte ratio (NLR) has been recognized as a poor prognostic indicator in various solid tumors. METHODS: We retrospectively analyzed 530 patients with de novo DLBCL who were diagnosed from April 2002 to November 2017. RESULTS: The median age of patients was 69 (range, 20...

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Autores principales: Azuma, Yoshiko, Nakaya, Aya, Fujita, Shinya, Satake, Atsushi, Nakanishi, Takahisa, Tsubokura, Yukie, Saito, Ryo, Konishi, Akiko, Hotta, Masaaki, Yoshimura, Hideaki, Ishii, Kazuyoshi, Ito, Tomoki, Nomura, Shosaku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551461/
https://www.ncbi.nlm.nih.gov/pubmed/31194040
http://dx.doi.org/10.1016/j.lrr.2019.100173
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author Azuma, Yoshiko
Nakaya, Aya
Fujita, Shinya
Satake, Atsushi
Nakanishi, Takahisa
Tsubokura, Yukie
Saito, Ryo
Konishi, Akiko
Hotta, Masaaki
Yoshimura, Hideaki
Ishii, Kazuyoshi
Ito, Tomoki
Nomura, Shosaku
author_facet Azuma, Yoshiko
Nakaya, Aya
Fujita, Shinya
Satake, Atsushi
Nakanishi, Takahisa
Tsubokura, Yukie
Saito, Ryo
Konishi, Akiko
Hotta, Masaaki
Yoshimura, Hideaki
Ishii, Kazuyoshi
Ito, Tomoki
Nomura, Shosaku
author_sort Azuma, Yoshiko
collection PubMed
description BACKGROUND: Neutrophil-to-lymphocyte ratio (NLR) has been recognized as a poor prognostic indicator in various solid tumors. METHODS: We retrospectively analyzed 530 patients with de novo DLBCL who were diagnosed from April 2002 to November 2017. RESULTS: The median age of patients was 69 (range, 20–95) years, and 59% were male. The optimal cutoff for NLR was 5.2. NLR (5.2) was not associated with overall and progression free survival. CONCLUSION: Our study failed to reveal the predictive value of NLR and demonstrated that the NCCN-IPI might be the most powerful predictor in DLBCL.
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spelling pubmed-65514612019-06-10 Neutrophil-to-lymphocyte ratio (NLR) fails to predict outcome of diffuse large B cell lymphoma Azuma, Yoshiko Nakaya, Aya Fujita, Shinya Satake, Atsushi Nakanishi, Takahisa Tsubokura, Yukie Saito, Ryo Konishi, Akiko Hotta, Masaaki Yoshimura, Hideaki Ishii, Kazuyoshi Ito, Tomoki Nomura, Shosaku Leuk Res Rep Article BACKGROUND: Neutrophil-to-lymphocyte ratio (NLR) has been recognized as a poor prognostic indicator in various solid tumors. METHODS: We retrospectively analyzed 530 patients with de novo DLBCL who were diagnosed from April 2002 to November 2017. RESULTS: The median age of patients was 69 (range, 20–95) years, and 59% were male. The optimal cutoff for NLR was 5.2. NLR (5.2) was not associated with overall and progression free survival. CONCLUSION: Our study failed to reveal the predictive value of NLR and demonstrated that the NCCN-IPI might be the most powerful predictor in DLBCL. Elsevier 2019-05-25 /pmc/articles/PMC6551461/ /pubmed/31194040 http://dx.doi.org/10.1016/j.lrr.2019.100173 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Azuma, Yoshiko
Nakaya, Aya
Fujita, Shinya
Satake, Atsushi
Nakanishi, Takahisa
Tsubokura, Yukie
Saito, Ryo
Konishi, Akiko
Hotta, Masaaki
Yoshimura, Hideaki
Ishii, Kazuyoshi
Ito, Tomoki
Nomura, Shosaku
Neutrophil-to-lymphocyte ratio (NLR) fails to predict outcome of diffuse large B cell lymphoma
title Neutrophil-to-lymphocyte ratio (NLR) fails to predict outcome of diffuse large B cell lymphoma
title_full Neutrophil-to-lymphocyte ratio (NLR) fails to predict outcome of diffuse large B cell lymphoma
title_fullStr Neutrophil-to-lymphocyte ratio (NLR) fails to predict outcome of diffuse large B cell lymphoma
title_full_unstemmed Neutrophil-to-lymphocyte ratio (NLR) fails to predict outcome of diffuse large B cell lymphoma
title_short Neutrophil-to-lymphocyte ratio (NLR) fails to predict outcome of diffuse large B cell lymphoma
title_sort neutrophil-to-lymphocyte ratio (nlr) fails to predict outcome of diffuse large b cell lymphoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551461/
https://www.ncbi.nlm.nih.gov/pubmed/31194040
http://dx.doi.org/10.1016/j.lrr.2019.100173
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