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CORO1C expression is associated with poor survival rates in gastric cancer and promotes metastasis in vitro

Coronin‐like actin‐binding protein 1C (CORO1C) is a member of the WD repeat protein family that regulates actin‐dependent processes by assembling F‐actin. CORO1C was previously reported to promote metastasis in breast cancer and lung squamous cell carcinoma. Here, we investigated the role of CORO1C...

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Autores principales: Cheng, Xiao, Wang, Xiaonan, Wu, Zhengsheng, Tan, Sheng, Zhu, Tao, Ding, Keshuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551501/
https://www.ncbi.nlm.nih.gov/pubmed/30974047
http://dx.doi.org/10.1002/2211-5463.12639
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author Cheng, Xiao
Wang, Xiaonan
Wu, Zhengsheng
Tan, Sheng
Zhu, Tao
Ding, Keshuo
author_facet Cheng, Xiao
Wang, Xiaonan
Wu, Zhengsheng
Tan, Sheng
Zhu, Tao
Ding, Keshuo
author_sort Cheng, Xiao
collection PubMed
description Coronin‐like actin‐binding protein 1C (CORO1C) is a member of the WD repeat protein family that regulates actin‐dependent processes by assembling F‐actin. CORO1C was previously reported to promote metastasis in breast cancer and lung squamous cell carcinoma. Here, we investigated the role of CORO1C in gastric cancer. Higher expression levels of CORO1C were detected in gastric cancer tissues as compared with normal gastric tissues. In addition, CORO1C levels were found to be positively correlated with lymph node metastasis in gastric cancer patients. The expression levels of CORO1C were higher in stage III‐IV gastric cancer patients (80.8%) than in stage I‐II gastric cancer patients(57.1%). Gastric cancer patients positive for CORO1C expression showed lower relapse‐free survival and overall survival rates. Knockdown of CORO1C dramatically suppressed total cell number, cell viability, cell colony formation, cell mitosis and cell metastasis, and promoted apoptosis of gastric cancer cells. Furthermore, cyclin D1 and vimentin were found to be positively regulated by CORO1C. As cyclin D1 and vimentin play an oncogenic role in gastric cancer, CORO1C may exert its tumor‐promoting activity through these proteins.
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spelling pubmed-65515012019-06-10 CORO1C expression is associated with poor survival rates in gastric cancer and promotes metastasis in vitro Cheng, Xiao Wang, Xiaonan Wu, Zhengsheng Tan, Sheng Zhu, Tao Ding, Keshuo FEBS Open Bio Research Articles Coronin‐like actin‐binding protein 1C (CORO1C) is a member of the WD repeat protein family that regulates actin‐dependent processes by assembling F‐actin. CORO1C was previously reported to promote metastasis in breast cancer and lung squamous cell carcinoma. Here, we investigated the role of CORO1C in gastric cancer. Higher expression levels of CORO1C were detected in gastric cancer tissues as compared with normal gastric tissues. In addition, CORO1C levels were found to be positively correlated with lymph node metastasis in gastric cancer patients. The expression levels of CORO1C were higher in stage III‐IV gastric cancer patients (80.8%) than in stage I‐II gastric cancer patients(57.1%). Gastric cancer patients positive for CORO1C expression showed lower relapse‐free survival and overall survival rates. Knockdown of CORO1C dramatically suppressed total cell number, cell viability, cell colony formation, cell mitosis and cell metastasis, and promoted apoptosis of gastric cancer cells. Furthermore, cyclin D1 and vimentin were found to be positively regulated by CORO1C. As cyclin D1 and vimentin play an oncogenic role in gastric cancer, CORO1C may exert its tumor‐promoting activity through these proteins. John Wiley and Sons Inc. 2019-04-29 /pmc/articles/PMC6551501/ /pubmed/30974047 http://dx.doi.org/10.1002/2211-5463.12639 Text en © 2019 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Cheng, Xiao
Wang, Xiaonan
Wu, Zhengsheng
Tan, Sheng
Zhu, Tao
Ding, Keshuo
CORO1C expression is associated with poor survival rates in gastric cancer and promotes metastasis in vitro
title CORO1C expression is associated with poor survival rates in gastric cancer and promotes metastasis in vitro
title_full CORO1C expression is associated with poor survival rates in gastric cancer and promotes metastasis in vitro
title_fullStr CORO1C expression is associated with poor survival rates in gastric cancer and promotes metastasis in vitro
title_full_unstemmed CORO1C expression is associated with poor survival rates in gastric cancer and promotes metastasis in vitro
title_short CORO1C expression is associated with poor survival rates in gastric cancer and promotes metastasis in vitro
title_sort coro1c expression is associated with poor survival rates in gastric cancer and promotes metastasis in vitro
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551501/
https://www.ncbi.nlm.nih.gov/pubmed/30974047
http://dx.doi.org/10.1002/2211-5463.12639
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