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Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme

Enzymes that act on multiple substrates are common in biology but pose unique challenges as therapeutic targets. The metalloprotease insulin-degrading enzyme (IDE) modulates blood glucose levels by cleaving insulin, a hormone that promotes glucose clearance. However, IDE also degrades glucagon, a ho...

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Detalles Bibliográficos
Autores principales:	Maianti, Juan Pablo, Tan, Grace A., Vetere, Amedeo, Welsh, Amie J., Wagner, Bridget K., Seeliger, Markus A., Liu, David R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551522/ https://www.ncbi.nlm.nih.gov/pubmed/31086331 http://dx.doi.org/10.1038/s41589-019-0271-0

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