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Frontopolar cortex activation associated with pessimistic future-thinking in adults with major depressive disorder

BACKGROUND: Pessimistic thinking about the future is one of the cardinal symptoms of major depressive disorder (MDD) and is an important domain of cognitive functioning associated with hopelessness. Neuroimaging studies have shown that the frontopolar cortex (Brodmann area [BA] 10) is involved in th...

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Autores principales: Katayama, Nariko, Nakagawa, Atsuo, Umeda, Satoshi, Terasawa, Yuri, Kurata, Chika, Tabuchi, Hajime, Kikuchi, Toshiaki, Mimura, Masaru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551553/
https://www.ncbi.nlm.nih.gov/pubmed/31170685
http://dx.doi.org/10.1016/j.nicl.2019.101877
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author Katayama, Nariko
Nakagawa, Atsuo
Umeda, Satoshi
Terasawa, Yuri
Kurata, Chika
Tabuchi, Hajime
Kikuchi, Toshiaki
Mimura, Masaru
author_facet Katayama, Nariko
Nakagawa, Atsuo
Umeda, Satoshi
Terasawa, Yuri
Kurata, Chika
Tabuchi, Hajime
Kikuchi, Toshiaki
Mimura, Masaru
author_sort Katayama, Nariko
collection PubMed
description BACKGROUND: Pessimistic thinking about the future is one of the cardinal symptoms of major depressive disorder (MDD) and is an important domain of cognitive functioning associated with hopelessness. Neuroimaging studies have shown that the frontopolar cortex (Brodmann area [BA] 10) is involved in thinking about the future and demonstrated that patients with MDD have dysfunctions in BA10. However, the relationship between pessimistic thinking about the future and brain activity is unclear. Hence, we aimed to compare brain activity during future-thinking between patients with MDD and healthy individuals. METHODS: We assessed 23 patients with current MDD and 23 healthy individuals. Participants were instructed to imagine the future or to recall the past using the future-thinking paradigm with four distinct temporal conditions (distant future, near future, distant past, and near past) during functional MRI. Resting-state functional MRI was also performed to explore the functional connectivity of BA10. RESULTS: Compared with healthy individuals, patients with MDD had greater negative thinking about the distant future and exhibited increased activation in the medial BA10 when imagining the distant future, following small-volume correction focusing on the frontopolar a priori region of interest (family-wise error correction p < 0.05). Increased positive functional correlation between the right BA10 seed region and the posterior cingulate cortex was also observed. CONCLUSION: Patients with MDD who show greater pessimistic thinking about the distant future demonstrate increased activation in the frontopolar cortex. These findings are consistent with the hypothesis that frontopolar cortical dysfunction plays a key role in the hopelessness that manifests in patients with MDD.
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spelling pubmed-65515532019-06-10 Frontopolar cortex activation associated with pessimistic future-thinking in adults with major depressive disorder Katayama, Nariko Nakagawa, Atsuo Umeda, Satoshi Terasawa, Yuri Kurata, Chika Tabuchi, Hajime Kikuchi, Toshiaki Mimura, Masaru Neuroimage Clin Regular Article BACKGROUND: Pessimistic thinking about the future is one of the cardinal symptoms of major depressive disorder (MDD) and is an important domain of cognitive functioning associated with hopelessness. Neuroimaging studies have shown that the frontopolar cortex (Brodmann area [BA] 10) is involved in thinking about the future and demonstrated that patients with MDD have dysfunctions in BA10. However, the relationship between pessimistic thinking about the future and brain activity is unclear. Hence, we aimed to compare brain activity during future-thinking between patients with MDD and healthy individuals. METHODS: We assessed 23 patients with current MDD and 23 healthy individuals. Participants were instructed to imagine the future or to recall the past using the future-thinking paradigm with four distinct temporal conditions (distant future, near future, distant past, and near past) during functional MRI. Resting-state functional MRI was also performed to explore the functional connectivity of BA10. RESULTS: Compared with healthy individuals, patients with MDD had greater negative thinking about the distant future and exhibited increased activation in the medial BA10 when imagining the distant future, following small-volume correction focusing on the frontopolar a priori region of interest (family-wise error correction p < 0.05). Increased positive functional correlation between the right BA10 seed region and the posterior cingulate cortex was also observed. CONCLUSION: Patients with MDD who show greater pessimistic thinking about the distant future demonstrate increased activation in the frontopolar cortex. These findings are consistent with the hypothesis that frontopolar cortical dysfunction plays a key role in the hopelessness that manifests in patients with MDD. Elsevier 2019-05-28 /pmc/articles/PMC6551553/ /pubmed/31170685 http://dx.doi.org/10.1016/j.nicl.2019.101877 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Katayama, Nariko
Nakagawa, Atsuo
Umeda, Satoshi
Terasawa, Yuri
Kurata, Chika
Tabuchi, Hajime
Kikuchi, Toshiaki
Mimura, Masaru
Frontopolar cortex activation associated with pessimistic future-thinking in adults with major depressive disorder
title Frontopolar cortex activation associated with pessimistic future-thinking in adults with major depressive disorder
title_full Frontopolar cortex activation associated with pessimistic future-thinking in adults with major depressive disorder
title_fullStr Frontopolar cortex activation associated with pessimistic future-thinking in adults with major depressive disorder
title_full_unstemmed Frontopolar cortex activation associated with pessimistic future-thinking in adults with major depressive disorder
title_short Frontopolar cortex activation associated with pessimistic future-thinking in adults with major depressive disorder
title_sort frontopolar cortex activation associated with pessimistic future-thinking in adults with major depressive disorder
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551553/
https://www.ncbi.nlm.nih.gov/pubmed/31170685
http://dx.doi.org/10.1016/j.nicl.2019.101877
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