SAT-036 Extracellular Domain Calcium-Sensing Receptor (CaSR) Mutations Leading to Hypercalcemic and Hypocalcemic Disorders Cluster at the Homodimeric Interface

The calcium-sensing receptor (CaSR) is a homodimeric G-protein coupled receptor that plays a pivotal role in extracellular Ca(2+) (Ca(2+)(e)) homeostasis, and loss- and gain-of-function mutations of the CaSR cause familial hypocalciuric hypercalcemia type 1 (FHH1) and autosomal dominant hypocalcemia...

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Detalles Bibliográficos
Autores principales: Olesen, Mie, Gorvin, Caroline, Thakker, Rajesh, Hannan, Fadil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2019
Materias:
Non-Steroid Hormone Signaling
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551669/
http://dx.doi.org/10.1210/js.2019-SAT-036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551669/
http://dx.doi.org/10.1210/js.2019-SAT-036

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