Regulation of T cell antitumor immune response by tumor induced metabolic stress

Adaptive T cell immune response is essential for tumor growth control. The efficacy of immune checkpoint inhibitors is regulated by intratumoral immune response. The tumor microenvironment has a major role in adaptive immune response tuning. Tumor cells generate a particular metabolic environment in...

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Detalles Bibliográficos
Autores principales: Chalmin, Fanny, Bruchard, Mélanie, Vegran, Frederique, Ghiringhelli, Francois
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551678/
https://www.ncbi.nlm.nih.gov/pubmed/31225495
http://dx.doi.org/10.15698/cst2019.01.171
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author Chalmin, Fanny
Bruchard, Mélanie
Vegran, Frederique
Ghiringhelli, Francois
author_facet Chalmin, Fanny
Bruchard, Mélanie
Vegran, Frederique
Ghiringhelli, Francois
author_sort Chalmin, Fanny
collection PubMed
description Adaptive T cell immune response is essential for tumor growth control. The efficacy of immune checkpoint inhibitors is regulated by intratumoral immune response. The tumor microenvironment has a major role in adaptive immune response tuning. Tumor cells generate a particular metabolic environment in comparison to other tissues. Tumors are characterized by glycolysis, hypoxia, acidosis, amino acid depletion and fatty acid metabolism modification. Such metabolic changes promote tumor growth, impair immune response and lead to resistance to therapies. This review will detail how these modifications strongly affect CD8 and CD4 T cell functions and impact immunotherapy efficacy.
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spelling pubmed-65516782019-06-20 Regulation of T cell antitumor immune response by tumor induced metabolic stress Chalmin, Fanny Bruchard, Mélanie Vegran, Frederique Ghiringhelli, Francois Cell Stress Review Adaptive T cell immune response is essential for tumor growth control. The efficacy of immune checkpoint inhibitors is regulated by intratumoral immune response. The tumor microenvironment has a major role in adaptive immune response tuning. Tumor cells generate a particular metabolic environment in comparison to other tissues. Tumors are characterized by glycolysis, hypoxia, acidosis, amino acid depletion and fatty acid metabolism modification. Such metabolic changes promote tumor growth, impair immune response and lead to resistance to therapies. This review will detail how these modifications strongly affect CD8 and CD4 T cell functions and impact immunotherapy efficacy. Shared Science Publishers OG 2018-11-27 /pmc/articles/PMC6551678/ /pubmed/31225495 http://dx.doi.org/10.15698/cst2019.01.171 Text en Copyright: © 2019 Chalmin et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
spellingShingle Review
Chalmin, Fanny
Bruchard, Mélanie
Vegran, Frederique
Ghiringhelli, Francois
Regulation of T cell antitumor immune response by tumor induced metabolic stress
title Regulation of T cell antitumor immune response by tumor induced metabolic stress
title_full Regulation of T cell antitumor immune response by tumor induced metabolic stress
title_fullStr Regulation of T cell antitumor immune response by tumor induced metabolic stress
title_full_unstemmed Regulation of T cell antitumor immune response by tumor induced metabolic stress
title_short Regulation of T cell antitumor immune response by tumor induced metabolic stress
title_sort regulation of t cell antitumor immune response by tumor induced metabolic stress
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551678/
https://www.ncbi.nlm.nih.gov/pubmed/31225495
http://dx.doi.org/10.15698/cst2019.01.171
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AT ghiringhellifrancois regulationoftcellantitumorimmuneresponsebytumorinducedmetabolicstress

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