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miR34a: a master regulator in the pathogenesis of bronchopulmonary dysplasia
Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease in infants with lifelong pulmonary and neurodevelopmental consequences. The pathogenesis of BPD is contributed by genetic and environmental factors; among the latter, a critical contributor is exposure of the developing lung to...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shared Science Publishers OG
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551723/ https://www.ncbi.nlm.nih.gov/pubmed/31225464 http://dx.doi.org/10.15698/cst2018.02.1224 |
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author | Das, Pragnya Syed, Mansoor Ali Shah, Dilip Bhandari, Vineet |
author_facet | Das, Pragnya Syed, Mansoor Ali Shah, Dilip Bhandari, Vineet |
author_sort | Das, Pragnya |
collection | PubMed |
description | Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease in infants with lifelong pulmonary and neurodevelopmental consequences. The pathogenesis of BPD is contributed by genetic and environmental factors; among the latter, a critical contributor is exposure of the developing lung to hyperoxia. We have recently reported (Nat Comm 8:1173) that hyperoxia exposure in our in vitro and in vivo modeling systems of hyperoxia-induced lung injury (HALI) and BPD leads to an upregulation of the microRNA (miR) 34a. Utilizing genetic loss- and gain- of function strategies, we show that miR34a inhibition ameliorates the pulmonary phenotype of BPD (including BPD-associated pulmonary hypertension), at least in part, via one of the downstream targets of miR34a, namely Angiopoietin1/Tie 2 signaling. In addition, we demonstrate translational clinical significance of our findings by showing increased miR34a and decreased Ang1 expression in 3 independent cohorts of human lung samples. |
format | Online Article Text |
id | pubmed-6551723 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Shared Science Publishers OG |
record_format | MEDLINE/PubMed |
spelling | pubmed-65517232019-06-20 miR34a: a master regulator in the pathogenesis of bronchopulmonary dysplasia Das, Pragnya Syed, Mansoor Ali Shah, Dilip Bhandari, Vineet Cell Stress Microreview Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease in infants with lifelong pulmonary and neurodevelopmental consequences. The pathogenesis of BPD is contributed by genetic and environmental factors; among the latter, a critical contributor is exposure of the developing lung to hyperoxia. We have recently reported (Nat Comm 8:1173) that hyperoxia exposure in our in vitro and in vivo modeling systems of hyperoxia-induced lung injury (HALI) and BPD leads to an upregulation of the microRNA (miR) 34a. Utilizing genetic loss- and gain- of function strategies, we show that miR34a inhibition ameliorates the pulmonary phenotype of BPD (including BPD-associated pulmonary hypertension), at least in part, via one of the downstream targets of miR34a, namely Angiopoietin1/Tie 2 signaling. In addition, we demonstrate translational clinical significance of our findings by showing increased miR34a and decreased Ang1 expression in 3 independent cohorts of human lung samples. Shared Science Publishers OG 2018-01-09 /pmc/articles/PMC6551723/ /pubmed/31225464 http://dx.doi.org/10.15698/cst2018.02.1224 Text en Copyright: © 2018 Das et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged. |
spellingShingle | Microreview Das, Pragnya Syed, Mansoor Ali Shah, Dilip Bhandari, Vineet miR34a: a master regulator in the pathogenesis of bronchopulmonary dysplasia |
title | miR34a: a master regulator in the pathogenesis of bronchopulmonary dysplasia |
title_full | miR34a: a master regulator in the pathogenesis of bronchopulmonary dysplasia |
title_fullStr | miR34a: a master regulator in the pathogenesis of bronchopulmonary dysplasia |
title_full_unstemmed | miR34a: a master regulator in the pathogenesis of bronchopulmonary dysplasia |
title_short | miR34a: a master regulator in the pathogenesis of bronchopulmonary dysplasia |
title_sort | mir34a: a master regulator in the pathogenesis of bronchopulmonary dysplasia |
topic | Microreview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551723/ https://www.ncbi.nlm.nih.gov/pubmed/31225464 http://dx.doi.org/10.15698/cst2018.02.1224 |
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