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miR34a: a master regulator in the pathogenesis of bronchopulmonary dysplasia

Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease in infants with lifelong pulmonary and neurodevelopmental consequences. The pathogenesis of BPD is contributed by genetic and environmental factors; among the latter, a critical contributor is exposure of the developing lung to...

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Detalles Bibliográficos
Autores principales: Das, Pragnya, Syed, Mansoor Ali, Shah, Dilip, Bhandari, Vineet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551723/
https://www.ncbi.nlm.nih.gov/pubmed/31225464
http://dx.doi.org/10.15698/cst2018.02.1224
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author Das, Pragnya
Syed, Mansoor Ali
Shah, Dilip
Bhandari, Vineet
author_facet Das, Pragnya
Syed, Mansoor Ali
Shah, Dilip
Bhandari, Vineet
author_sort Das, Pragnya
collection PubMed
description Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease in infants with lifelong pulmonary and neurodevelopmental consequences. The pathogenesis of BPD is contributed by genetic and environmental factors; among the latter, a critical contributor is exposure of the developing lung to hyperoxia. We have recently reported (Nat Comm 8:1173) that hyperoxia exposure in our in vitro and in vivo modeling systems of hyperoxia-induced lung injury (HALI) and BPD leads to an upregulation of the microRNA (miR) 34a. Utilizing genetic loss- and gain- of function strategies, we show that miR34a inhibition ameliorates the pulmonary phenotype of BPD (including BPD-associated pulmonary hypertension), at least in part, via one of the downstream targets of miR34a, namely Angiopoietin1/Tie 2 signaling. In addition, we demonstrate translational clinical significance of our findings by showing increased miR34a and decreased Ang1 expression in 3 independent cohorts of human lung samples.
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spelling pubmed-65517232019-06-20 miR34a: a master regulator in the pathogenesis of bronchopulmonary dysplasia Das, Pragnya Syed, Mansoor Ali Shah, Dilip Bhandari, Vineet Cell Stress Microreview Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease in infants with lifelong pulmonary and neurodevelopmental consequences. The pathogenesis of BPD is contributed by genetic and environmental factors; among the latter, a critical contributor is exposure of the developing lung to hyperoxia. We have recently reported (Nat Comm 8:1173) that hyperoxia exposure in our in vitro and in vivo modeling systems of hyperoxia-induced lung injury (HALI) and BPD leads to an upregulation of the microRNA (miR) 34a. Utilizing genetic loss- and gain- of function strategies, we show that miR34a inhibition ameliorates the pulmonary phenotype of BPD (including BPD-associated pulmonary hypertension), at least in part, via one of the downstream targets of miR34a, namely Angiopoietin1/Tie 2 signaling. In addition, we demonstrate translational clinical significance of our findings by showing increased miR34a and decreased Ang1 expression in 3 independent cohorts of human lung samples. Shared Science Publishers OG 2018-01-09 /pmc/articles/PMC6551723/ /pubmed/31225464 http://dx.doi.org/10.15698/cst2018.02.1224 Text en Copyright: © 2018 Das et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
spellingShingle Microreview
Das, Pragnya
Syed, Mansoor Ali
Shah, Dilip
Bhandari, Vineet
miR34a: a master regulator in the pathogenesis of bronchopulmonary dysplasia
title miR34a: a master regulator in the pathogenesis of bronchopulmonary dysplasia
title_full miR34a: a master regulator in the pathogenesis of bronchopulmonary dysplasia
title_fullStr miR34a: a master regulator in the pathogenesis of bronchopulmonary dysplasia
title_full_unstemmed miR34a: a master regulator in the pathogenesis of bronchopulmonary dysplasia
title_short miR34a: a master regulator in the pathogenesis of bronchopulmonary dysplasia
title_sort mir34a: a master regulator in the pathogenesis of bronchopulmonary dysplasia
topic Microreview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551723/
https://www.ncbi.nlm.nih.gov/pubmed/31225464
http://dx.doi.org/10.15698/cst2018.02.1224
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