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Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase

Alzheimer´s disease (AD) is a devastating neurodegenerative disease of the elderly population. Genetic evidence strongly suggests that aberrant generation and/or clearance of the neurotoxic amyloid-β peptide (Aβ) is triggering the disease. Aβ is generated from the amyloid precursor protein (APP) by...

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Detalles Bibliográficos
Autores principales:	Steiner, Harald, Fukumori, Akio, Tagami, Shinji, Okochi, Masayasu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Shared Science Publishers OG 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551803/ https://www.ncbi.nlm.nih.gov/pubmed/31225454 http://dx.doi.org/10.15698/cst2018.11.162

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