Human monocyte-to-macrophage differentiation involves highly localized gain and loss of DNA methylation at transcription factor binding sites

BACKGROUND: Macrophages and their precursors monocytes play a key role in inflammation and chronic inflammatory disorders. Monocyte-to-macrophage differentiation and activation programs are accompanied by significant epigenetic remodeling where DNA methylation associates with cell identity. Here we...

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Detalles Bibliográficos
Autores principales: Dekkers, Koen F., Neele, Annette E., Jukema, J. Wouter, Heijmans, Bastiaan T., de Winther, Menno P. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551876/
https://www.ncbi.nlm.nih.gov/pubmed/31171035
http://dx.doi.org/10.1186/s13072-019-0279-4

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