The role of interleukin-1 in general pathology

Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological functions and pathological significances and play an important role in health and disease. In this decade, interleukin-1 family members have been expanding and evidence is accumulating that highlights the importance...

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Autores principales: Kaneko, Naoe, Kurata, Mie, Yamamoto, Toshihiro, Morikawa, Shinnosuke, Masumoto, Junya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551897/
https://www.ncbi.nlm.nih.gov/pubmed/31182982
http://dx.doi.org/10.1186/s41232-019-0101-5
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author Kaneko, Naoe
Kurata, Mie
Yamamoto, Toshihiro
Morikawa, Shinnosuke
Masumoto, Junya
author_facet Kaneko, Naoe
Kurata, Mie
Yamamoto, Toshihiro
Morikawa, Shinnosuke
Masumoto, Junya
author_sort Kaneko, Naoe
collection PubMed
description Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological functions and pathological significances and play an important role in health and disease. In this decade, interleukin-1 family members have been expanding and evidence is accumulating that highlights the importance of interleukin-1 in linking innate immunity with a broad spectrum of diseases beyond inflammatory diseases. In this review, we look back on the definition of “inflammation” in traditional general pathology and discuss new insights into interleukin-1 in view of its history and the molecular bases of diseases, as well as current progress in therapeutics.
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spelling pubmed-65518972019-06-10 The role of interleukin-1 in general pathology Kaneko, Naoe Kurata, Mie Yamamoto, Toshihiro Morikawa, Shinnosuke Masumoto, Junya Inflamm Regen Review Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological functions and pathological significances and play an important role in health and disease. In this decade, interleukin-1 family members have been expanding and evidence is accumulating that highlights the importance of interleukin-1 in linking innate immunity with a broad spectrum of diseases beyond inflammatory diseases. In this review, we look back on the definition of “inflammation” in traditional general pathology and discuss new insights into interleukin-1 in view of its history and the molecular bases of diseases, as well as current progress in therapeutics. BioMed Central 2019-06-06 /pmc/articles/PMC6551897/ /pubmed/31182982 http://dx.doi.org/10.1186/s41232-019-0101-5 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Kaneko, Naoe
Kurata, Mie
Yamamoto, Toshihiro
Morikawa, Shinnosuke
Masumoto, Junya
The role of interleukin-1 in general pathology
title The role of interleukin-1 in general pathology
title_full The role of interleukin-1 in general pathology
title_fullStr The role of interleukin-1 in general pathology
title_full_unstemmed The role of interleukin-1 in general pathology
title_short The role of interleukin-1 in general pathology
title_sort role of interleukin-1 in general pathology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551897/
https://www.ncbi.nlm.nih.gov/pubmed/31182982
http://dx.doi.org/10.1186/s41232-019-0101-5
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