Cargando…
MR-guidance in clinical reality: current treatment challenges and future perspectives
Magnetic Resonance-guided radiotherapy (MRgRT) marks the beginning of a new era. MR is a versatile and suitable imaging modality for radiotherapy, as it enables direct visualization of the tumor and the surrounding organs at risk. Moreover, MRgRT provides real-time imaging to characterize and eventu...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551911/ https://www.ncbi.nlm.nih.gov/pubmed/31167658 http://dx.doi.org/10.1186/s13014-019-1308-y |
_version_ | 1783424483452780544 |
---|---|
author | Corradini, S. Alongi, F. Andratschke, N. Belka, C. Boldrini, L. Cellini, F. Debus, J. Guckenberger, M. Hörner-Rieber, J. Lagerwaard, F. J. Mazzola, R. Palacios, M. A. Philippens, M. E. P. Raaijmakers, C. P. J. Terhaard, C. H. J. Valentini, V. Niyazi, M. |
author_facet | Corradini, S. Alongi, F. Andratschke, N. Belka, C. Boldrini, L. Cellini, F. Debus, J. Guckenberger, M. Hörner-Rieber, J. Lagerwaard, F. J. Mazzola, R. Palacios, M. A. Philippens, M. E. P. Raaijmakers, C. P. J. Terhaard, C. H. J. Valentini, V. Niyazi, M. |
author_sort | Corradini, S. |
collection | PubMed |
description | Magnetic Resonance-guided radiotherapy (MRgRT) marks the beginning of a new era. MR is a versatile and suitable imaging modality for radiotherapy, as it enables direct visualization of the tumor and the surrounding organs at risk. Moreover, MRgRT provides real-time imaging to characterize and eventually track anatomical motion. Nevertheless, the successful translation of new technologies into clinical practice remains challenging. To date, the initial availability of next-generation hybrid MR-linac (MRL) systems is still limited and therefore, the focus of the present preview was on the initial applicability in current clinical practice and on future perspectives of this new technology for different treatment sites. MRgRT can be considered a groundbreaking new technology that is capable of creating new perspectives towards an individualized, patient-oriented planning and treatment approach, especially due to the ability to use daily online adaptation strategies. Furthermore, MRL systems overcome the limitations of conventional image-guided radiotherapy, especially in soft tissue, where target and organs at risk need accurate definition. Nevertheless, some concerns remain regarding the additional time needed to re-optimize dose distributions online, the reliability of the gating and tracking procedures and the interpretation of functional MR imaging markers and their potential changes during the course of treatment. Due to its continuous technological improvement and rapid clinical large-scale application in several anatomical settings, further studies may confirm the potential disruptive role of MRgRT in the evolving oncological environment. |
format | Online Article Text |
id | pubmed-6551911 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-65519112019-06-07 MR-guidance in clinical reality: current treatment challenges and future perspectives Corradini, S. Alongi, F. Andratschke, N. Belka, C. Boldrini, L. Cellini, F. Debus, J. Guckenberger, M. Hörner-Rieber, J. Lagerwaard, F. J. Mazzola, R. Palacios, M. A. Philippens, M. E. P. Raaijmakers, C. P. J. Terhaard, C. H. J. Valentini, V. Niyazi, M. Radiat Oncol Review Magnetic Resonance-guided radiotherapy (MRgRT) marks the beginning of a new era. MR is a versatile and suitable imaging modality for radiotherapy, as it enables direct visualization of the tumor and the surrounding organs at risk. Moreover, MRgRT provides real-time imaging to characterize and eventually track anatomical motion. Nevertheless, the successful translation of new technologies into clinical practice remains challenging. To date, the initial availability of next-generation hybrid MR-linac (MRL) systems is still limited and therefore, the focus of the present preview was on the initial applicability in current clinical practice and on future perspectives of this new technology for different treatment sites. MRgRT can be considered a groundbreaking new technology that is capable of creating new perspectives towards an individualized, patient-oriented planning and treatment approach, especially due to the ability to use daily online adaptation strategies. Furthermore, MRL systems overcome the limitations of conventional image-guided radiotherapy, especially in soft tissue, where target and organs at risk need accurate definition. Nevertheless, some concerns remain regarding the additional time needed to re-optimize dose distributions online, the reliability of the gating and tracking procedures and the interpretation of functional MR imaging markers and their potential changes during the course of treatment. Due to its continuous technological improvement and rapid clinical large-scale application in several anatomical settings, further studies may confirm the potential disruptive role of MRgRT in the evolving oncological environment. BioMed Central 2019-06-03 /pmc/articles/PMC6551911/ /pubmed/31167658 http://dx.doi.org/10.1186/s13014-019-1308-y Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Corradini, S. Alongi, F. Andratschke, N. Belka, C. Boldrini, L. Cellini, F. Debus, J. Guckenberger, M. Hörner-Rieber, J. Lagerwaard, F. J. Mazzola, R. Palacios, M. A. Philippens, M. E. P. Raaijmakers, C. P. J. Terhaard, C. H. J. Valentini, V. Niyazi, M. MR-guidance in clinical reality: current treatment challenges and future perspectives |
title | MR-guidance in clinical reality: current treatment challenges and future perspectives |
title_full | MR-guidance in clinical reality: current treatment challenges and future perspectives |
title_fullStr | MR-guidance in clinical reality: current treatment challenges and future perspectives |
title_full_unstemmed | MR-guidance in clinical reality: current treatment challenges and future perspectives |
title_short | MR-guidance in clinical reality: current treatment challenges and future perspectives |
title_sort | mr-guidance in clinical reality: current treatment challenges and future perspectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551911/ https://www.ncbi.nlm.nih.gov/pubmed/31167658 http://dx.doi.org/10.1186/s13014-019-1308-y |
work_keys_str_mv | AT corradinis mrguidanceinclinicalrealitycurrenttreatmentchallengesandfutureperspectives AT alongif mrguidanceinclinicalrealitycurrenttreatmentchallengesandfutureperspectives AT andratschken mrguidanceinclinicalrealitycurrenttreatmentchallengesandfutureperspectives AT belkac mrguidanceinclinicalrealitycurrenttreatmentchallengesandfutureperspectives AT boldrinil mrguidanceinclinicalrealitycurrenttreatmentchallengesandfutureperspectives AT cellinif mrguidanceinclinicalrealitycurrenttreatmentchallengesandfutureperspectives AT debusj mrguidanceinclinicalrealitycurrenttreatmentchallengesandfutureperspectives AT guckenbergerm mrguidanceinclinicalrealitycurrenttreatmentchallengesandfutureperspectives AT hornerrieberj mrguidanceinclinicalrealitycurrenttreatmentchallengesandfutureperspectives AT lagerwaardfj mrguidanceinclinicalrealitycurrenttreatmentchallengesandfutureperspectives AT mazzolar mrguidanceinclinicalrealitycurrenttreatmentchallengesandfutureperspectives AT palaciosma mrguidanceinclinicalrealitycurrenttreatmentchallengesandfutureperspectives AT philippensmep mrguidanceinclinicalrealitycurrenttreatmentchallengesandfutureperspectives AT raaijmakerscpj mrguidanceinclinicalrealitycurrenttreatmentchallengesandfutureperspectives AT terhaardchj mrguidanceinclinicalrealitycurrenttreatmentchallengesandfutureperspectives AT valentiniv mrguidanceinclinicalrealitycurrenttreatmentchallengesandfutureperspectives AT niyazim mrguidanceinclinicalrealitycurrenttreatmentchallengesandfutureperspectives |