Bradykinin sensitizes the cough reflex via a B(2) receptor dependent activation of TRPV1 and TRPA1 channels through metabolites of cyclooxygenase and 12-lipoxygenase

BACKGROUND: Inhaled bradykinin (BK) has been reported to both sensitize and induce cough but whether BK can centrally sensitize the cough reflex is not fully established. In this study, using a conscious guinea-pig model of cough, we investigated the role of BK in the central sensitization of the co...

Descripción completa

Detalles Bibliográficos
Autores principales: Al-Shamlan, Fajer, El-Hashim, Ahmed Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551914/
https://www.ncbi.nlm.nih.gov/pubmed/31170972
http://dx.doi.org/10.1186/s12931-019-1060-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551914/
https://www.ncbi.nlm.nih.gov/pubmed/31170972
http://dx.doi.org/10.1186/s12931-019-1060-8

Ejemplares similares