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Bradykinin sensitizes the cough reflex via a B(2) receptor dependent activation of TRPV1 and TRPA1 channels through metabolites of cyclooxygenase and 12-lipoxygenase

BACKGROUND: Inhaled bradykinin (BK) has been reported to both sensitize and induce cough but whether BK can centrally sensitize the cough reflex is not fully established. In this study, using a conscious guinea-pig model of cough, we investigated the role of BK in the central sensitization of the co...

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Detalles Bibliográficos
Autores principales:	Al-Shamlan, Fajer, El-Hashim, Ahmed Z.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551914/ https://www.ncbi.nlm.nih.gov/pubmed/31170972 http://dx.doi.org/10.1186/s12931-019-1060-8

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