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SAT-LB073 SJX-653, a Novel Selective NK3 Antagonist, Demonstrates Activity on Pharmacodynamic Markers of NK3 Target Engagement

Background: NK3 antagonism is a clinically validated mechanism of action for treating menopausal vasomotor symptoms (“hot flashes”). In men, reductions of LH and T are sensitive pharmacodynamic markers of central NK3 antagonism, due to the known inhibitory effect of NK3 antagonists on GnRH pulsatili...

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Detalles Bibliográficos
Autores principales:	Cormier, Jennifer, Boyce, Malcolm, van den Berg, Frans, Grau, Daniel, Turnquist, David, Corzo, Deya, Graham, Philip
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Endocrine Society 2019
Materias:	Neuroendocrinology and Pituitary
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552009/ http://dx.doi.org/10.1210/js.2019-SAT-LB073

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