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SAT-455 Analysis of a Group of Prolactinomas Resistant to Treatment with Dopamine Agonists at a University Hospital in Buenos Aires, Argentina
Prolactinomas represent approximately 40-60% of all pituitary tumors. Dopamine agonists (DA) are the first-line treatment, with a 70-90% response. However, up to 10% are resistant (R) to DA. Our objectives were to describe the clinical, biochemical and imaging characteristics of a group of patients...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Endocrine Society
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552054/ http://dx.doi.org/10.1210/js.2019-SAT-455 |
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author | Gonzalez Pernas, Mariana Sosa, Soledad Manavela, Marcos Gonzalez Abbati, Santiago Bruno, Oscar Danilowicz, Karina |
author_facet | Gonzalez Pernas, Mariana Sosa, Soledad Manavela, Marcos Gonzalez Abbati, Santiago Bruno, Oscar Danilowicz, Karina |
author_sort | Gonzalez Pernas, Mariana |
collection | PubMed |
description | Prolactinomas represent approximately 40-60% of all pituitary tumors. Dopamine agonists (DA) are the first-line treatment, with a 70-90% response. However, up to 10% are resistant (R) to DA. Our objectives were to describe the clinical, biochemical and imaging characteristics of a group of patients with prolactinomas R to DA; and to determine the presence of prognostic factors by performing a comparative analysis with the population of non-R prolactinomas. We analized retrospectively the medical records of patients diagnosed with prolactinoma, with follow-up (f-up) at the same hospital from 1998 to 2017. They were classified as R when prolactin (PRL) was not normalized and/or a reduction ≤ than 50% of the tumor (Tx) volumen, with a cabergoline (CBG) dose ≥2mg/week (mg/w), with, at least 6 months of treatment. Macroadenomas (MA) were defined as Tx ≥10mm and as invasive with a classification of Knosp 3 or 4 by MRI. Of 95 prolactinomas, 14 patients with R to DA were described. The mean age was 32.7 ± 15.6 years (y). We found no statistically significant differences (SSD) in terms of gender, with a higher distribution (53%) and a tendency to age (37.9 vs 26.9, p = 0.09) in the male gender (M). The mean time of f-up was 34.7 ± 28.7 months (m). Majority were MA (87%) and invasive Tx (64%). The initial manifestations were: headache (85.7%), visual field alteration (50%), menstrual cycle alterations (86%), galactorrhea (20%). The mean PRL value was 7419.4 ± 1149.7 ng/ml, being higher in the M group (11652.6 vs 1653.3, p <0.001). 93% of the patients received CBG as the main treatment. The mean dose was 6.8 ± 4.3 mg/w, with a mean time of 34.3 ± 23.1 m. 57% of the patients achieved a reduction ≥ 50% of PRL, 2 normalized it. 4 patients presented ≥ 50% reduction in Tx size. All were MA, invasive, none normalized PRL, in 3/4 surgical resolution was indicated. When comparing with the population of non-R prolactinomas (n = 81), we found a higher proportion of M with a statistical tendency in the R group (p=0.053) and a greater proportion of MA (p=0.04) and invasive (p = 0.03). Higher values of PRL were evident at diagnosis in this group (508.9 vs 7482.5, p <0.0001), higher dose of CBG (1.8 vs 6.6, p <0.001), but without SSD in the time of use of DA, the age at diagnosis or the time of f-up. A value of PRL at diagnosis above 1065 ng/mL has a specificity of 85% for R. Patients in the non-R group had a biochemical response ≥ 50% with the treatment (p<0.001), but not in terms of the structural response (p=0.13) nor in the biochemical response time (p=0.12). Similar to that reported in the literature, we evidenced a frequency of 15% of R in our population. In contrast to classic prolactinomas, a greater proportion of R Tx was found in the M gender, in MA and with invasive characteristics. We can conclude that larger Tx with a higher PRL value at the time of diagnosis and, probably, the M gender are more likely to present R to DA |
format | Online Article Text |
id | pubmed-6552054 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Endocrine Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-65520542019-06-13 SAT-455 Analysis of a Group of Prolactinomas Resistant to Treatment with Dopamine Agonists at a University Hospital in Buenos Aires, Argentina Gonzalez Pernas, Mariana Sosa, Soledad Manavela, Marcos Gonzalez Abbati, Santiago Bruno, Oscar Danilowicz, Karina J Endocr Soc Neuroendocrinology and Pituitary Prolactinomas represent approximately 40-60% of all pituitary tumors. Dopamine agonists (DA) are the first-line treatment, with a 70-90% response. However, up to 10% are resistant (R) to DA. Our objectives were to describe the clinical, biochemical and imaging characteristics of a group of patients with prolactinomas R to DA; and to determine the presence of prognostic factors by performing a comparative analysis with the population of non-R prolactinomas. We analized retrospectively the medical records of patients diagnosed with prolactinoma, with follow-up (f-up) at the same hospital from 1998 to 2017. They were classified as R when prolactin (PRL) was not normalized and/or a reduction ≤ than 50% of the tumor (Tx) volumen, with a cabergoline (CBG) dose ≥2mg/week (mg/w), with, at least 6 months of treatment. Macroadenomas (MA) were defined as Tx ≥10mm and as invasive with a classification of Knosp 3 or 4 by MRI. Of 95 prolactinomas, 14 patients with R to DA were described. The mean age was 32.7 ± 15.6 years (y). We found no statistically significant differences (SSD) in terms of gender, with a higher distribution (53%) and a tendency to age (37.9 vs 26.9, p = 0.09) in the male gender (M). The mean time of f-up was 34.7 ± 28.7 months (m). Majority were MA (87%) and invasive Tx (64%). The initial manifestations were: headache (85.7%), visual field alteration (50%), menstrual cycle alterations (86%), galactorrhea (20%). The mean PRL value was 7419.4 ± 1149.7 ng/ml, being higher in the M group (11652.6 vs 1653.3, p <0.001). 93% of the patients received CBG as the main treatment. The mean dose was 6.8 ± 4.3 mg/w, with a mean time of 34.3 ± 23.1 m. 57% of the patients achieved a reduction ≥ 50% of PRL, 2 normalized it. 4 patients presented ≥ 50% reduction in Tx size. All were MA, invasive, none normalized PRL, in 3/4 surgical resolution was indicated. When comparing with the population of non-R prolactinomas (n = 81), we found a higher proportion of M with a statistical tendency in the R group (p=0.053) and a greater proportion of MA (p=0.04) and invasive (p = 0.03). Higher values of PRL were evident at diagnosis in this group (508.9 vs 7482.5, p <0.0001), higher dose of CBG (1.8 vs 6.6, p <0.001), but without SSD in the time of use of DA, the age at diagnosis or the time of f-up. A value of PRL at diagnosis above 1065 ng/mL has a specificity of 85% for R. Patients in the non-R group had a biochemical response ≥ 50% with the treatment (p<0.001), but not in terms of the structural response (p=0.13) nor in the biochemical response time (p=0.12). Similar to that reported in the literature, we evidenced a frequency of 15% of R in our population. In contrast to classic prolactinomas, a greater proportion of R Tx was found in the M gender, in MA and with invasive characteristics. We can conclude that larger Tx with a higher PRL value at the time of diagnosis and, probably, the M gender are more likely to present R to DA Endocrine Society 2019-04-30 /pmc/articles/PMC6552054/ http://dx.doi.org/10.1210/js.2019-SAT-455 Text en Copyright © 2019 Endocrine Society https://creativecommons.org/licenses/by-nc-nd/4.0/ This article has been published under the terms of the Creative Commons Attribution Non-Commercial, No-Derivatives License (CC BY-NC-ND; https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Neuroendocrinology and Pituitary Gonzalez Pernas, Mariana Sosa, Soledad Manavela, Marcos Gonzalez Abbati, Santiago Bruno, Oscar Danilowicz, Karina SAT-455 Analysis of a Group of Prolactinomas Resistant to Treatment with Dopamine Agonists at a University Hospital in Buenos Aires, Argentina |
title | SAT-455 Analysis of a Group of Prolactinomas Resistant to Treatment with Dopamine Agonists at a University Hospital in Buenos Aires, Argentina |
title_full | SAT-455 Analysis of a Group of Prolactinomas Resistant to Treatment with Dopamine Agonists at a University Hospital in Buenos Aires, Argentina |
title_fullStr | SAT-455 Analysis of a Group of Prolactinomas Resistant to Treatment with Dopamine Agonists at a University Hospital in Buenos Aires, Argentina |
title_full_unstemmed | SAT-455 Analysis of a Group of Prolactinomas Resistant to Treatment with Dopamine Agonists at a University Hospital in Buenos Aires, Argentina |
title_short | SAT-455 Analysis of a Group of Prolactinomas Resistant to Treatment with Dopamine Agonists at a University Hospital in Buenos Aires, Argentina |
title_sort | sat-455 analysis of a group of prolactinomas resistant to treatment with dopamine agonists at a university hospital in buenos aires, argentina |
topic | Neuroendocrinology and Pituitary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552054/ http://dx.doi.org/10.1210/js.2019-SAT-455 |
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