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SAT-040 Structural Mechanisms of Parathyroid Hormone (PTH) Binding to Receptor and Regulation of Endosomal Signaling

The parathyroid hormone (PTH) type 1 receptor (PTHR) is a key regulator of bone turnover and calcium homeostasis. PTHR primarily activates the stimulatory G-protein, Gs, for adenylate cyclases that induce the production of cAMP. Our laboratory has demonstrated that PTH stimulates both transient and...

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Detalles Bibliográficos
Autores principales:	Clark, Lisa, Bondarenko, Vasyl, Tang, Pei, Vilardaga, Jean-Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Endocrine Society 2019
Materias:	Non-Steroid Hormone Signaling
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552142/ http://dx.doi.org/10.1210/js.2019-SAT-040

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