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Circulating biomarkers in chronic thromboembolic pulmonary hypertension

Chronic thromboembolic pulmonary hypertension (CTEPH) is a serious condition characterized with chronic organized thrombi that obstruct the pulmonary vessels, leading to pulmonary hypertension (PH) and ultimately right heart failure. Although CTEPH is the only form of PH that can be cured with surgi...

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Autores principales: Zhang, Meng, Zhang, Yunxia, Pang, Wenyi, Zhai, Zhenguo, Wang, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552358/
https://www.ncbi.nlm.nih.gov/pubmed/30942132
http://dx.doi.org/10.1177/2045894019844480
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author Zhang, Meng
Zhang, Yunxia
Pang, Wenyi
Zhai, Zhenguo
Wang, Chen
author_facet Zhang, Meng
Zhang, Yunxia
Pang, Wenyi
Zhai, Zhenguo
Wang, Chen
author_sort Zhang, Meng
collection PubMed
description Chronic thromboembolic pulmonary hypertension (CTEPH) is a serious condition characterized with chronic organized thrombi that obstruct the pulmonary vessels, leading to pulmonary hypertension (PH) and ultimately right heart failure. Although CTEPH is the only form of PH that can be cured with surgical intervention, not all patients with CTEPH will be deemed operable. Some CTEPH patients still have a poor prognosis. Therefore, the determination of diagnostic and prognostic biomarkers of CTEPH is of great importance for the early intervention to improve prognosis of patients with CTEPH. Several markers related to multiple mechanisms of CTEPH have been recently identified as circulating diagnostic and prognostic biomarkers in these patients. However, the existing literature review of biomarkers of CTEPH is relatively sparse. In this article, we review recent advances in circulating biomarkers of CTEPH and describe future applications of these biomarkers in the management of CTEPH.
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spelling pubmed-65523582019-06-17 Circulating biomarkers in chronic thromboembolic pulmonary hypertension Zhang, Meng Zhang, Yunxia Pang, Wenyi Zhai, Zhenguo Wang, Chen Pulm Circ Review Article Chronic thromboembolic pulmonary hypertension (CTEPH) is a serious condition characterized with chronic organized thrombi that obstruct the pulmonary vessels, leading to pulmonary hypertension (PH) and ultimately right heart failure. Although CTEPH is the only form of PH that can be cured with surgical intervention, not all patients with CTEPH will be deemed operable. Some CTEPH patients still have a poor prognosis. Therefore, the determination of diagnostic and prognostic biomarkers of CTEPH is of great importance for the early intervention to improve prognosis of patients with CTEPH. Several markers related to multiple mechanisms of CTEPH have been recently identified as circulating diagnostic and prognostic biomarkers in these patients. However, the existing literature review of biomarkers of CTEPH is relatively sparse. In this article, we review recent advances in circulating biomarkers of CTEPH and describe future applications of these biomarkers in the management of CTEPH. SAGE Publications 2019-06-04 /pmc/articles/PMC6552358/ /pubmed/30942132 http://dx.doi.org/10.1177/2045894019844480 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review Article
Zhang, Meng
Zhang, Yunxia
Pang, Wenyi
Zhai, Zhenguo
Wang, Chen
Circulating biomarkers in chronic thromboembolic pulmonary hypertension
title Circulating biomarkers in chronic thromboembolic pulmonary hypertension
title_full Circulating biomarkers in chronic thromboembolic pulmonary hypertension
title_fullStr Circulating biomarkers in chronic thromboembolic pulmonary hypertension
title_full_unstemmed Circulating biomarkers in chronic thromboembolic pulmonary hypertension
title_short Circulating biomarkers in chronic thromboembolic pulmonary hypertension
title_sort circulating biomarkers in chronic thromboembolic pulmonary hypertension
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552358/
https://www.ncbi.nlm.nih.gov/pubmed/30942132
http://dx.doi.org/10.1177/2045894019844480
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