SAT-043 A Trafficking Defective Mutant PROKR2, Identified In Patients With Hypogonadotropic Hypogonadism, Cycles Between Endoplasmic Reticulum (ER) And Golgi To Attenuate ER Stress

G protein-coupled receptors (GPCRs) are the largest family of transmembrane proteins and are a major class of therapeutic drug targets. Mutations in GPCRs resulting in loss of function or alteration of signaling can cause inherited or acquired diseases. Such mutations frequently cause impaired cell...

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Detalles Bibliográficos
Autores principales: Song, Yong Bhum, Park, Seung-Yeol, Carroll, Rona, Hsu, Victor, Kaiser, Ursula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2019
Materias:
Non-Steroid Hormone Signaling
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552373/
http://dx.doi.org/10.1210/js.2019-SAT-043

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