SAT-249 Comparison of Different Criteria for the Definition of Insulin Resistance and Its Relation with Metabolic Risk in Overweight and Obese Adolescents

Purpose:The aim of this study is to compare cut off points corrected for age and gender (CCOP) with fixed cut off points (FCOP) for fasting plasma insulin and Homeostatic model assessment insulin resistance (HOMA-IR) for the diagnosis of IR in obese adolescents and their relation with metabolic abnormalities. Method: We performed a cross sectional analysis of data from 195 adolescents aged 12-18 years who participated in Korean National Health and Nutrition Examination Survey (KNHANEA, 2009-2010). Overweight and obese individuals were defined by BMI z score>1. Insulin resistance was defined as two critenia: FCOP of CCOP. Results; The prevalence of insulin resistance using HOMA-IR in FCOP and COOP was 105 (53.8%) and 127 (65.1%) respectively. The prevalence of insulin resistance using fasting plasma insulin was FCOP 120 (61.5%) and CCOP 151 (77.4%). Dyslipidemia, abdominal obesity and metabolic syndrome were not related to FCOP or CCOP. Fasting blood glucose remained in normal ranges in all patients with IR. Conclusion: More cases of IR were detected in CCOP of plasma insulin or of HOMA IR compared to the FCOP, but were not associated with incidence of metabolic disease. There is no fluctuation of blood glucose in this age group, even though presence of IR, and there is no significant difference in fasting plasma insulin between IR detected by HOMA-IR and by fasting insulin.