Cargando…

SAT-369 Proposal of Optimal Cutoff value for Serum Cortisol after an Overnight 1-mg Dexamethasone Suppression Test - Results from Multicenter Collaborative Research in Japan.

In Japan, diagnostic criteria of subclinical Cushing’s syndrome (SCS) were formulated in 1996, using cutoff value for serum cortisol of 3.0 μg/dL after an overnight 1-mg dexamethasone suppression test (DST). It has made considerable contributions to the understanding and pathology of SCS. However, i...

Descripción completa

Detalles Bibliográficos
Autores principales: Tanabe, Makito, Oki, Yutaka, Katabami, Takuyuki, Otsuki, Michio, Kageyama, Kazunori, Tanaka, Tomoaki, Kawate, Hisaya, Doi, Masaru, Akehi, Yuko, Ichijo, Takamasa, Yanase, Toshihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552520/
http://dx.doi.org/10.1210/js.2019-SAT-369
_version_ 1783424611428335616
author Tanabe, Makito
Oki, Yutaka
Katabami, Takuyuki
Otsuki, Michio
Kageyama, Kazunori
Tanaka, Tomoaki
Kawate, Hisaya
Doi, Masaru
Akehi, Yuko
Ichijo, Takamasa
Yanase, Toshihiko
author_facet Tanabe, Makito
Oki, Yutaka
Katabami, Takuyuki
Otsuki, Michio
Kageyama, Kazunori
Tanaka, Tomoaki
Kawate, Hisaya
Doi, Masaru
Akehi, Yuko
Ichijo, Takamasa
Yanase, Toshihiko
author_sort Tanabe, Makito
collection PubMed
description In Japan, diagnostic criteria of subclinical Cushing’s syndrome (SCS) were formulated in 1996, using cutoff value for serum cortisol of 3.0 μg/dL after an overnight 1-mg dexamethasone suppression test (DST). It has made considerable contributions to the understanding and pathology of SCS. However, it has elicited two main problems: (i) the relatively low reliability of a low range of serum cortisol essential for the diagnosis by DST; (ii) different cutoff values for serum cortisol after a 1-mg DST compared with those of other countries. For the proposal of new diagnostic criteria, we conducted a retrospective cross-sectional study. 530 cases (270 men and 260 women, mean age: 60.1 ± 11.1 years) with an adrenal tumor were assessed. In the present study, the assay kits adopted for measurement of serum cortisol differed among facilities. A calibration formula was previously developed by Kuwa et al. for standardization of different kits. Using this formula, standardization of the serum cortisol values after a 1-mg DST and at night was done. As a result, using current criteria, the diagnosis of 11 out of 92 SCS cases was changed to “non-SCS”, and all of 189 non-SCS cases remained non-SCS after calibration. After all, diagnostic concordance rate before and after calibration was 96.1%, suggesting that the actual diagnosis did not change dramatically, by calibration. The cortisol values after a 1-mg DST were compared based on the presence or absence of complications (hypertension, impaired glucose tolerance or diabetes, and hypercholesterolemia). As a result, when serum cortisol after a 1-mg DST was stratified by increments of 1.0 μg/dL, the coincidental occurrence of hypertension and impaired glucose tolerance was more frequently observed in the 2-2.99 μg/dL group than in the 0-0.99 μg/dL group (39.3% vs. 23.5%, p=0.018), suggesting that the threshold for the onset of complications of adrenal tumors may be serum cortisol of 2-3μg/dL after a 1-mg DST. Under the consideration of international consistency, serum cortisol ≥1.8 μg/dL after a 1-mg DST may be useful for the detection of ‘not completely healthy’ subjects with adrenal tumor. Additionally, in the present study, almost all of the respective criteria, such as basal ACTH <10 pg/mL and/or nocturnal cortisol at 21.00-23.00 h ≥5 μg/dL, are satisfied in almost all cases who have serum cortisol ≥5 μg/dL after a 1-mg DST. It suggests that serum cortisol ≥5 μg/dL after a 1-mg DST warrant the significant autonomy of cortisol production. The current cutoff level of 3.0 μg/dL may be also useful, for lowering the risk of confusion in the application of new diagnostic criteria. Consequently, three hierarchical cortisol cutoff values, 5.0, 3.0 and 1.8 μg/dL are presented to the new diagnostic criteria of SCS in Japan.
format Online
Article
Text
id pubmed-6552520
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Endocrine Society
record_format MEDLINE/PubMed
spelling pubmed-65525202019-06-13 SAT-369 Proposal of Optimal Cutoff value for Serum Cortisol after an Overnight 1-mg Dexamethasone Suppression Test - Results from Multicenter Collaborative Research in Japan. Tanabe, Makito Oki, Yutaka Katabami, Takuyuki Otsuki, Michio Kageyama, Kazunori Tanaka, Tomoaki Kawate, Hisaya Doi, Masaru Akehi, Yuko Ichijo, Takamasa Yanase, Toshihiko J Endocr Soc Adrenal In Japan, diagnostic criteria of subclinical Cushing’s syndrome (SCS) were formulated in 1996, using cutoff value for serum cortisol of 3.0 μg/dL after an overnight 1-mg dexamethasone suppression test (DST). It has made considerable contributions to the understanding and pathology of SCS. However, it has elicited two main problems: (i) the relatively low reliability of a low range of serum cortisol essential for the diagnosis by DST; (ii) different cutoff values for serum cortisol after a 1-mg DST compared with those of other countries. For the proposal of new diagnostic criteria, we conducted a retrospective cross-sectional study. 530 cases (270 men and 260 women, mean age: 60.1 ± 11.1 years) with an adrenal tumor were assessed. In the present study, the assay kits adopted for measurement of serum cortisol differed among facilities. A calibration formula was previously developed by Kuwa et al. for standardization of different kits. Using this formula, standardization of the serum cortisol values after a 1-mg DST and at night was done. As a result, using current criteria, the diagnosis of 11 out of 92 SCS cases was changed to “non-SCS”, and all of 189 non-SCS cases remained non-SCS after calibration. After all, diagnostic concordance rate before and after calibration was 96.1%, suggesting that the actual diagnosis did not change dramatically, by calibration. The cortisol values after a 1-mg DST were compared based on the presence or absence of complications (hypertension, impaired glucose tolerance or diabetes, and hypercholesterolemia). As a result, when serum cortisol after a 1-mg DST was stratified by increments of 1.0 μg/dL, the coincidental occurrence of hypertension and impaired glucose tolerance was more frequently observed in the 2-2.99 μg/dL group than in the 0-0.99 μg/dL group (39.3% vs. 23.5%, p=0.018), suggesting that the threshold for the onset of complications of adrenal tumors may be serum cortisol of 2-3μg/dL after a 1-mg DST. Under the consideration of international consistency, serum cortisol ≥1.8 μg/dL after a 1-mg DST may be useful for the detection of ‘not completely healthy’ subjects with adrenal tumor. Additionally, in the present study, almost all of the respective criteria, such as basal ACTH <10 pg/mL and/or nocturnal cortisol at 21.00-23.00 h ≥5 μg/dL, are satisfied in almost all cases who have serum cortisol ≥5 μg/dL after a 1-mg DST. It suggests that serum cortisol ≥5 μg/dL after a 1-mg DST warrant the significant autonomy of cortisol production. The current cutoff level of 3.0 μg/dL may be also useful, for lowering the risk of confusion in the application of new diagnostic criteria. Consequently, three hierarchical cortisol cutoff values, 5.0, 3.0 and 1.8 μg/dL are presented to the new diagnostic criteria of SCS in Japan. Endocrine Society 2019-04-30 /pmc/articles/PMC6552520/ http://dx.doi.org/10.1210/js.2019-SAT-369 Text en Copyright © 2019 Endocrine Society https://creativecommons.org/licenses/by-nc-nd/4.0/ This article has been published under the terms of the Creative Commons Attribution Non-Commercial, No-Derivatives License (CC BY-NC-ND; https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Adrenal
Tanabe, Makito
Oki, Yutaka
Katabami, Takuyuki
Otsuki, Michio
Kageyama, Kazunori
Tanaka, Tomoaki
Kawate, Hisaya
Doi, Masaru
Akehi, Yuko
Ichijo, Takamasa
Yanase, Toshihiko
SAT-369 Proposal of Optimal Cutoff value for Serum Cortisol after an Overnight 1-mg Dexamethasone Suppression Test - Results from Multicenter Collaborative Research in Japan.
title SAT-369 Proposal of Optimal Cutoff value for Serum Cortisol after an Overnight 1-mg Dexamethasone Suppression Test - Results from Multicenter Collaborative Research in Japan.
title_full SAT-369 Proposal of Optimal Cutoff value for Serum Cortisol after an Overnight 1-mg Dexamethasone Suppression Test - Results from Multicenter Collaborative Research in Japan.
title_fullStr SAT-369 Proposal of Optimal Cutoff value for Serum Cortisol after an Overnight 1-mg Dexamethasone Suppression Test - Results from Multicenter Collaborative Research in Japan.
title_full_unstemmed SAT-369 Proposal of Optimal Cutoff value for Serum Cortisol after an Overnight 1-mg Dexamethasone Suppression Test - Results from Multicenter Collaborative Research in Japan.
title_short SAT-369 Proposal of Optimal Cutoff value for Serum Cortisol after an Overnight 1-mg Dexamethasone Suppression Test - Results from Multicenter Collaborative Research in Japan.
title_sort sat-369 proposal of optimal cutoff value for serum cortisol after an overnight 1-mg dexamethasone suppression test - results from multicenter collaborative research in japan.
topic Adrenal
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552520/
http://dx.doi.org/10.1210/js.2019-SAT-369
work_keys_str_mv AT tanabemakito sat369proposalofoptimalcutoffvalueforserumcortisolafteranovernight1mgdexamethasonesuppressiontestresultsfrommulticentercollaborativeresearchinjapan
AT okiyutaka sat369proposalofoptimalcutoffvalueforserumcortisolafteranovernight1mgdexamethasonesuppressiontestresultsfrommulticentercollaborativeresearchinjapan
AT katabamitakuyuki sat369proposalofoptimalcutoffvalueforserumcortisolafteranovernight1mgdexamethasonesuppressiontestresultsfrommulticentercollaborativeresearchinjapan
AT otsukimichio sat369proposalofoptimalcutoffvalueforserumcortisolafteranovernight1mgdexamethasonesuppressiontestresultsfrommulticentercollaborativeresearchinjapan
AT kageyamakazunori sat369proposalofoptimalcutoffvalueforserumcortisolafteranovernight1mgdexamethasonesuppressiontestresultsfrommulticentercollaborativeresearchinjapan
AT tanakatomoaki sat369proposalofoptimalcutoffvalueforserumcortisolafteranovernight1mgdexamethasonesuppressiontestresultsfrommulticentercollaborativeresearchinjapan
AT kawatehisaya sat369proposalofoptimalcutoffvalueforserumcortisolafteranovernight1mgdexamethasonesuppressiontestresultsfrommulticentercollaborativeresearchinjapan
AT doimasaru sat369proposalofoptimalcutoffvalueforserumcortisolafteranovernight1mgdexamethasonesuppressiontestresultsfrommulticentercollaborativeresearchinjapan
AT akehiyuko sat369proposalofoptimalcutoffvalueforserumcortisolafteranovernight1mgdexamethasonesuppressiontestresultsfrommulticentercollaborativeresearchinjapan
AT ichijotakamasa sat369proposalofoptimalcutoffvalueforserumcortisolafteranovernight1mgdexamethasonesuppressiontestresultsfrommulticentercollaborativeresearchinjapan
AT yanasetoshihiko sat369proposalofoptimalcutoffvalueforserumcortisolafteranovernight1mgdexamethasonesuppressiontestresultsfrommulticentercollaborativeresearchinjapan