SUN-138 Association Between The Deficit Of 25 (oh) Vitamin D, Metabolic Syndrome And New Onset Of Type 2 Diabetes

INTRODUCTION: Low levels of vitamin D are associated with insulin resistance, β-cell dysfunction and poor insulin secretion. Since the metabolic syndrome (MS), diabetes and 25 (OH) D deficiency have a high prevalence; Establishing an association between them is important. OBJECTIVES: 1) To evaluate the inverse association between levels of 25 (OH) D and metabolic syndrome 2)Evaluate the relationship between 25 (OH) D and diabetes. MATERIALS AND METHODS A cross-sectional case-control study was conducted in male and female patients over 18 years of age. Data on weight, height, body mass index, waist circumference and blood pressure were collected. Samples were taken for glycemia, total cholesterol, ldl, hdl, triglycerides, 25 (OH) D, calcemia, insulinemia and HOMA-IR was calculated. According to body mass index, they were classified as overweight (25-29.9 kg / m2), obesity type I (30-34.9 kg / m2), type II (35 - 39.9 kg / m2), type III ( > 40 kg / m2). It was classified as deficient 25 (OH) D <30 ng / ml, insufficiency <20 ng / ml and severe insufficiency <10 ng / ml. The SM was defined according to ATP III criteria. For the diagnosis of diabetes mellitus criteria of the Argentine Diabetes Society were used. RESULTS 299 patients were analyzed. An inverse association between 25 (OH) D and SM was found in both men and women. The deficit of 25 (OH) D is greater in those who have waist circumference greater than 102 cm in men and greater 88 cm in women (p = 0.0096). Deficit of 25 (OH) D is greater in those who have triglycerides greater than 150 mg / dL (p = 0.004). Deficit of 25 (OH) D is greater in those with fasting blood glucose greater than 100mg / dL (p = 0.0012). The deficit of 25 (OH) D is lower in those who have normal weight and there is no significant growth with the obesity categories (p = 0.024). A ROC curve establishes the cut-off point of 26 ng / ml to discriminate the risk of developing MS depending on the value of 25 (OH) D: sensitivity 72.2%, 95% confidence interval (65.1, 78.6 ), specificity 66.4%; 95% CI (57.2, 74.8). The area under the ROC curve is 0.697 (p = <0.0001), with 95% CI(0.641, 0.748). It can not be affirmed that there is an association between systolic or diastolic BP and deficit 25 (OH) D (p = 0.0825). The average of 25 (OH) D is higher in individuals who do not have diabetes (p = 0.0096). Patients with a deficit of 25 (OH) D, according to odds ratios adjusted by sex and age, are 4.9 times more likely to develop type 2 diabetes with respect to a patient without deficit; and a male patient has 1.88 times the chance of having DBT 2 compared to a woman. CONCLUSION: Hypovitaminosis D has an inverse and significant correlation with MS and its different variables with the exception of blood pressure. An inverse and significant relationship was also found with the risk of developing type 2 diabetes. The deficit of 25 (OH) D is lower within patients normal weigth and there is no significant growth among the obesity categories.