SUN-084 Aged Insulin Resistant Macrophages Reveal Dysregulated Cholesterol Biosynthesis, Pro-Inflammatory Gene Expression, and Reduced Foam Cell Formation

Insulin resistance is the central defining feature of type 2 diabetes and increases with age. People with type 2 diabetes are at a significantly increased risk of developing atherosclerosis. Macrophages are phagocytotic leukocytes which play a central role in the development of type 2 diabetes and a...

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Detalles Bibliográficos
Autores principales: Chabrier, Gwladys, Hobson, Sam, Yuldasheva, Nadira, Kearney, Mark, Schurmans, Stephane, Pineda Torra, Ines, Gage, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2019
Materias:
Cardiovascular Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552898/
http://dx.doi.org/10.1210/js.2019-SUN-084

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