Light chain lambda myeloma with fatal AL cardiac amyloidosis in a 21‐year‐old patient: A case report and review

Multi‐organ AL amyloidosis is a therapeutic challenge because of light chain deposits severely damaging the function of concerned organs. Cardiac involvement, which leads to concentric hypertrophy of both ventricles, is particularly severe and leads to poor prognosis regardless of combination chemot...

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Detalles Bibliográficos
Autores principales: Camus, Vincent, Dubois, Sydney, Thiébaut, Pierre‐Alain, Lepretre, Stéphane, Lenain, Pascal, Picquenot, Jean‐Michel, Veresezan, Elena‐Liana, François, Arnaud, Penther, Dominique, Bauer, Fabrice, Jaccard, Arnaud, Jardin, Fabrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552948/
https://www.ncbi.nlm.nih.gov/pubmed/31183088
http://dx.doi.org/10.1002/ccr3.2165
Descripción
Sumario:Multi‐organ AL amyloidosis is a therapeutic challenge because of light chain deposits severely damaging the function of concerned organs. Cardiac involvement, which leads to concentric hypertrophy of both ventricles, is particularly severe and leads to poor prognosis regardless of combination chemotherapy. This case pinpoints the relevance of combining clinical, histological, and echocardiographic information in the management of this complex and life‐threatening disease.

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