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Substrate specificity-enabled terminal protection for direct quantification of circulating MicroRNA in patient serums
Currently, reported affinity pairings still lack in diversity, and thus terminal protection relying on steric hindrance is restricted in designing nucleic acid-based analytical systems. In this work, resistance to exonuclease is testified by group modification or backbone replacement, and the 3′-pho...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552989/ https://www.ncbi.nlm.nih.gov/pubmed/31293746 http://dx.doi.org/10.1039/c8sc05240a |