SUN-006 Lasofoxifene Achieves Potent Anti-Tumor Activity in Hormone-Resistant Breast Tumors by Maintaining High Affinity Binding for Y537S ERα

Activating somatic mutations to the ligand binding domain (LBD) of ESR1 (the gene for estrogen receptor alpha) may arise after prolonged hormone treatments. Y537S and D538G are the most prevalent mutations, accounting for 16% and 32% of cases respectively. Both mutations resist tamoxifen by favoring...

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Detalles Bibliográficos
Autores principales: Fanning, Sean, Laine, Muriel, Greene, Marianne, Chang, Ya-Fang, Phung, Linda, Green, Bradley, Hiipakka, Richard, Han, Ross, Komm, Barry, Greene, Geoffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2019
Materias:
Steroid Hormones and Receptors
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553177/
http://dx.doi.org/10.1210/js.2019-SUN-006

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