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SUN-069 Differences in Treatment of Peripheral Arterial Disease Procedures in Hospitalized Patients with Type 1 or 2 Diabetes

Introduction: Limited literature exists describing differences in treatment and outcomes following procedural admissions among individuals with peripheral arterial occlusive disease (PAD) based upon type of diabetes. Methods: Using the National (Nationwide) Inpatient Sample (NIS) database 2005 to 20...

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Autores principales: Jain, Nidhi, Agarwal, Manyoo, Dokun, Ayotunde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553366/
http://dx.doi.org/10.1210/js.2019-SUN-069
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author Jain, Nidhi
Agarwal, Manyoo
Dokun, Ayotunde
author_facet Jain, Nidhi
Agarwal, Manyoo
Dokun, Ayotunde
author_sort Jain, Nidhi
collection PubMed
description Introduction: Limited literature exists describing differences in treatment and outcomes following procedural admissions among individuals with peripheral arterial occlusive disease (PAD) based upon type of diabetes. Methods: Using the National (Nationwide) Inpatient Sample (NIS) database 2005 to 2014, we identified adult (age ≥ 18 years) diabetic patients with a diagnosis of PAD and a co-existing diagnosis of critical limb ischemia or intermittent claudication who underwent treatment procedures: open revascularization, endovascular revascularization or amputation. This unselected national cohort was then studied to analyze the differences in clinical characteristics, treatment procedures and outcomes based on presence of type of DM (Type 1 vs. Type 2). Results: Among 1,082,665 PAD related procedural admissions in diabetic population, 5.0% (n= 53,831) had Type 1 DM. Overall, Type 1 DM were younger, more likely to be white, males, have private insurance and less likely to have concurrent diagnoses of hypertension, smoking, dyslipidemia, coronary artery disease, congestive heart failure, atrial fibrillation, cerebrovascular disease and chronic pulmonary disease (all p <0.001). Type 1 DM group had significantly higher concurrent diagnoses of chronic renal failure. Type 1 DM patients were more likely to undergo amputation (60.7% vs. 47.9%, adjusted odds ratio = 1.39, 95% CI 1.35 to 1.42) and less likely to undergo endovascular (15.6% vs. 22.7%, adjusted odds ratio = 0.86, 95% CI 0.84 to 0.88) and open revascularization procedures (10.7% vs. 15.5%, adjusted odds ratio = 0.82, 95% CI 0.80 to 0.84). Overall in-hospital mortality was 1.8%; 1.9% in Type 1 and 1.8% in Type 2 DM. The overall median (IQR) length of stay (in days) was 7 (4 to 12); 8(5 to14) for Type 1 DM and 7(4 to 12) for Type 2 DM. Overall median hospitalization cost was 38,108 (20,110 to 72,328); 52, 659 (28,871 to 97, 209) for Type 1 DM and 52, 172 (30, 027 to 92, 824) for Type 2 DM. Conclusion: This is the first study to examine the differences in lower extremity PAD related procedural hospitalization based on type of diabetes. We observed that type 1 DM patients undergoing procedural hospitalizations were younger, preferentially were treated with amputations, and had higher length of stay when compared to those with type 2 DM.
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spelling pubmed-65533662019-06-13 SUN-069 Differences in Treatment of Peripheral Arterial Disease Procedures in Hospitalized Patients with Type 1 or 2 Diabetes Jain, Nidhi Agarwal, Manyoo Dokun, Ayotunde J Endocr Soc Cardiovascular Endocrinology Introduction: Limited literature exists describing differences in treatment and outcomes following procedural admissions among individuals with peripheral arterial occlusive disease (PAD) based upon type of diabetes. Methods: Using the National (Nationwide) Inpatient Sample (NIS) database 2005 to 2014, we identified adult (age ≥ 18 years) diabetic patients with a diagnosis of PAD and a co-existing diagnosis of critical limb ischemia or intermittent claudication who underwent treatment procedures: open revascularization, endovascular revascularization or amputation. This unselected national cohort was then studied to analyze the differences in clinical characteristics, treatment procedures and outcomes based on presence of type of DM (Type 1 vs. Type 2). Results: Among 1,082,665 PAD related procedural admissions in diabetic population, 5.0% (n= 53,831) had Type 1 DM. Overall, Type 1 DM were younger, more likely to be white, males, have private insurance and less likely to have concurrent diagnoses of hypertension, smoking, dyslipidemia, coronary artery disease, congestive heart failure, atrial fibrillation, cerebrovascular disease and chronic pulmonary disease (all p <0.001). Type 1 DM group had significantly higher concurrent diagnoses of chronic renal failure. Type 1 DM patients were more likely to undergo amputation (60.7% vs. 47.9%, adjusted odds ratio = 1.39, 95% CI 1.35 to 1.42) and less likely to undergo endovascular (15.6% vs. 22.7%, adjusted odds ratio = 0.86, 95% CI 0.84 to 0.88) and open revascularization procedures (10.7% vs. 15.5%, adjusted odds ratio = 0.82, 95% CI 0.80 to 0.84). Overall in-hospital mortality was 1.8%; 1.9% in Type 1 and 1.8% in Type 2 DM. The overall median (IQR) length of stay (in days) was 7 (4 to 12); 8(5 to14) for Type 1 DM and 7(4 to 12) for Type 2 DM. Overall median hospitalization cost was 38,108 (20,110 to 72,328); 52, 659 (28,871 to 97, 209) for Type 1 DM and 52, 172 (30, 027 to 92, 824) for Type 2 DM. Conclusion: This is the first study to examine the differences in lower extremity PAD related procedural hospitalization based on type of diabetes. We observed that type 1 DM patients undergoing procedural hospitalizations were younger, preferentially were treated with amputations, and had higher length of stay when compared to those with type 2 DM. Endocrine Society 2019-04-30 /pmc/articles/PMC6553366/ http://dx.doi.org/10.1210/js.2019-SUN-069 Text en Copyright © 2019 Endocrine Society https://creativecommons.org/licenses/by-nc-nd/4.0/ This article has been published under the terms of the Creative Commons Attribution Non-Commercial, No-Derivatives License (CC BY-NC-ND; https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Cardiovascular Endocrinology
Jain, Nidhi
Agarwal, Manyoo
Dokun, Ayotunde
SUN-069 Differences in Treatment of Peripheral Arterial Disease Procedures in Hospitalized Patients with Type 1 or 2 Diabetes
title SUN-069 Differences in Treatment of Peripheral Arterial Disease Procedures in Hospitalized Patients with Type 1 or 2 Diabetes
title_full SUN-069 Differences in Treatment of Peripheral Arterial Disease Procedures in Hospitalized Patients with Type 1 or 2 Diabetes
title_fullStr SUN-069 Differences in Treatment of Peripheral Arterial Disease Procedures in Hospitalized Patients with Type 1 or 2 Diabetes
title_full_unstemmed SUN-069 Differences in Treatment of Peripheral Arterial Disease Procedures in Hospitalized Patients with Type 1 or 2 Diabetes
title_short SUN-069 Differences in Treatment of Peripheral Arterial Disease Procedures in Hospitalized Patients with Type 1 or 2 Diabetes
title_sort sun-069 differences in treatment of peripheral arterial disease procedures in hospitalized patients with type 1 or 2 diabetes
topic Cardiovascular Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553366/
http://dx.doi.org/10.1210/js.2019-SUN-069
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