SUN-072 Elevated TyG Index Predicts Progression of Coronary Artery Calcification

Title: Elevated TyG index predicts progression of coronary artery calcification Objective: To investigate the TyG index association with coronary artery calcification(CAC) progression in adult Koreans. Research design and methods: Various cardiovascular risk factors and anthropometric profiles were assessed in 1175 subjects, who previously had CAC evaluation, at least twice, by multi-detector CT in a health care center. TyG index was determined using ln[fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. A difference of ≥ 2.5 units between the square roots of the baseline and follow-up coronary artery calcium scores (CACS) was considered as CAC progression. Results: CAC progression was seen in 282 subjects (24%) during 4.2 years follow-up. Based on TyG index, patients were stratified into three groups. Follow-up CACS and incidence of CAC progression markedly elevated with rising TyG index tertile. Logistic regression analysis adjusted for different risk factors, revealed the odds ratio for CAC progression to be 1.88 (95% CI: 1.21-2.92; P<0.01) when the highest and lowest TyG index tertiles were compared. Conclusion: TyG index is an independent predictor of CAC progression.