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Mutation of the ATPase Domain of MutS Homolog-5 (MSH5) Reveals a Requirement for a Functional MutSγ Complex for All Crossovers in Mammalian Meiosis

During meiosis, induction of DNA double strand breaks (DSB) leads to recombination between homologous chromosomes, resulting in crossovers (CO) and non-crossovers (NCO). In the mouse, only 10% of DSBs resolve as COs, mostly through a class I pathway dependent on MutSγ (MSH4/ MSH5) and MutLγ (MLH1/ML...

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Detalles Bibliográficos
Autores principales:	Milano, Carolyn R., Holloway, J. Kim, Zhang, Yongwei, Jin, Bo, Smith, Cameron, Bergman, Aviv, Edelmann, Winfried, Cohen, Paula E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2019
Materias:	Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553527/ https://www.ncbi.nlm.nih.gov/pubmed/30944090 http://dx.doi.org/10.1534/g3.119.400074

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