5-Hydroxymethylcytosine Profiles Are Prognostic of Outcome in Neuroblastoma and Reveal Transcriptional Networks That Correlate With Tumor Phenotype

PURPOSE: Whole-genome profiles of the epigenetic modification 5-hydroxymethylcytosine (5-hmC) are robust diagnostic biomarkers in adult patients with cancer. We investigated if 5-hmC profiles would serve as novel prognostic markers in neuroblastoma, a clinically heterogeneous pediatric cancer. Becau...

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Detalles Bibliográficos
Autores principales: Applebaum, Mark A., Barr, Erin K., Karpus, Jason, Nie, Ji, Zhang, Zhou, Armstrong, Amy E., Uppal, Sakshi, Sukhanova, Madina, Zhang, Wei, Chlenski, Alexandre, Salwen, Helen R., Wilkinson, Emma, Dobratic, Marija, Grossman, Robert, Godley, Lucy A., Stranger, Barbara E., He, Chuan, Cohn, Susan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Clinical Oncology 2019
Materias:
Original Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553657/
https://www.ncbi.nlm.nih.gov/pubmed/31179414
http://dx.doi.org/10.1200/PO.18.00402

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