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Ethylene Glycol Toxicity in the Setting of Recurrent Ingestion: A Case Report and Literature Review
Ethylene glycol (EG) poisoning is a toxicologic emergency requiring high clinical suspicion and early diagnosis to prevent life-threatening complications. Direct EG quantification methods involve cumbersome and time-consuming laboratory tests of limited utility in the emergency setting. Accordingly,...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553679/ https://www.ncbi.nlm.nih.gov/pubmed/31218140 http://dx.doi.org/10.7759/cureus.4375 |
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author | Loriaux, Daniel Bergin, Stephen P Patel, Sweta M Tucker, Jesse Barkauskas, Christina E |
author_facet | Loriaux, Daniel Bergin, Stephen P Patel, Sweta M Tucker, Jesse Barkauskas, Christina E |
author_sort | Loriaux, Daniel |
collection | PubMed |
description | Ethylene glycol (EG) poisoning is a toxicologic emergency requiring high clinical suspicion and early diagnosis to prevent life-threatening complications. Direct EG quantification methods involve cumbersome and time-consuming laboratory tests of limited utility in the emergency setting. Accordingly, the osmolal gap is frequently employed as a surrogate screening method in cases of suspected toxic alcohol poisoning. However, the osmolal gap has several inherent limitations to be considered when used as a diagnostic tool for EG toxicity. Although many of these limitations are widely acknowledged, the clinical finding of a normal serum osmolal gap in the setting of recurrent toxic alcohol exposure is an observation that has remained largely unexplored. The purpose of this case report is to characterize the accelerated osmolal gap to anion gap conversion that may occur in the setting of chronic toxic alcohol abuse. |
format | Online Article Text |
id | pubmed-6553679 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-65536792019-06-19 Ethylene Glycol Toxicity in the Setting of Recurrent Ingestion: A Case Report and Literature Review Loriaux, Daniel Bergin, Stephen P Patel, Sweta M Tucker, Jesse Barkauskas, Christina E Cureus Emergency Medicine Ethylene glycol (EG) poisoning is a toxicologic emergency requiring high clinical suspicion and early diagnosis to prevent life-threatening complications. Direct EG quantification methods involve cumbersome and time-consuming laboratory tests of limited utility in the emergency setting. Accordingly, the osmolal gap is frequently employed as a surrogate screening method in cases of suspected toxic alcohol poisoning. However, the osmolal gap has several inherent limitations to be considered when used as a diagnostic tool for EG toxicity. Although many of these limitations are widely acknowledged, the clinical finding of a normal serum osmolal gap in the setting of recurrent toxic alcohol exposure is an observation that has remained largely unexplored. The purpose of this case report is to characterize the accelerated osmolal gap to anion gap conversion that may occur in the setting of chronic toxic alcohol abuse. Cureus 2019-04-03 /pmc/articles/PMC6553679/ /pubmed/31218140 http://dx.doi.org/10.7759/cureus.4375 Text en Copyright © 2019, Loriaux et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Emergency Medicine Loriaux, Daniel Bergin, Stephen P Patel, Sweta M Tucker, Jesse Barkauskas, Christina E Ethylene Glycol Toxicity in the Setting of Recurrent Ingestion: A Case Report and Literature Review |
title | Ethylene Glycol Toxicity in the Setting of Recurrent Ingestion: A Case Report and Literature Review |
title_full | Ethylene Glycol Toxicity in the Setting of Recurrent Ingestion: A Case Report and Literature Review |
title_fullStr | Ethylene Glycol Toxicity in the Setting of Recurrent Ingestion: A Case Report and Literature Review |
title_full_unstemmed | Ethylene Glycol Toxicity in the Setting of Recurrent Ingestion: A Case Report and Literature Review |
title_short | Ethylene Glycol Toxicity in the Setting of Recurrent Ingestion: A Case Report and Literature Review |
title_sort | ethylene glycol toxicity in the setting of recurrent ingestion: a case report and literature review |
topic | Emergency Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553679/ https://www.ncbi.nlm.nih.gov/pubmed/31218140 http://dx.doi.org/10.7759/cureus.4375 |
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