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Epidemiological characteristics of holoprosencephaly in China, 2007-2014: A retrospective study based on the national birth defects surveillance system

OBJECTIVE: To describe the epidemiology of holoprosencephaly (HPE) in China with special reference to prevalence and associated anomalies. METHODS: Data were abstracted from the Chinese Birth Defects Monitoring Network for the period 2007–2014. Birth prevalence of HPE were assessed by birth year, fe...

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Autores principales: Yi, Ling, Liu, Zhongqiang, Deng, Changfei, Li, Xiaohong, Wang, Ke, Deng, Kui, Mu, Yi, Zhu, Jun, Li, Qi, Wang, Yanping, Dai, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553724/
https://www.ncbi.nlm.nih.gov/pubmed/31170204
http://dx.doi.org/10.1371/journal.pone.0217835
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author Yi, Ling
Liu, Zhongqiang
Deng, Changfei
Li, Xiaohong
Wang, Ke
Deng, Kui
Mu, Yi
Zhu, Jun
Li, Qi
Wang, Yanping
Dai, Li
author_facet Yi, Ling
Liu, Zhongqiang
Deng, Changfei
Li, Xiaohong
Wang, Ke
Deng, Kui
Mu, Yi
Zhu, Jun
Li, Qi
Wang, Yanping
Dai, Li
author_sort Yi, Ling
collection PubMed
description OBJECTIVE: To describe the epidemiology of holoprosencephaly (HPE) in China with special reference to prevalence and associated anomalies. METHODS: Data were abstracted from the Chinese Birth Defects Monitoring Network for the period 2007–2014. Birth prevalence of HPE were assessed by birth year, fetal/infant sex, maternal age, and maternal residential area. Poisson regressions were used to calculate the crude and adjusted prevalence ratios (PR) and their 95% confidence intervals, and linear chi-square test was used to explore time trend for the prevalence of HPE. RESULTS: A total of 1222 HPE cases were identified in 13,284,142 births, yielding an overall prevalence of 0.92 per 10,000 births. The annual prevalence of HPE presented an upward trend (P<0.001), from 0.54 per 10,000 births in 2007 to 1.21 per 10,000 births in 2014. Higher prevalence was found in older maternal-age groups (30–34 years, adjusted PR: 1.19, 95% CI: 1.02–1.40; ≥35 years, adjusted PR: 1.53, 95% CI: 1.26–1.86) in comparison with the maternal-age group of 25 to 29 years. Higher prevalence was also found in infants born to mothers resided in urban areas (adjusted PR: 1.23, 95% CI: 1.08–1.39) and female infants (adjusted PR: 1.30, 95% CI: 1.15–1.47). CONCLUSIONS: HPE is an important perinatal health issue because of its poor prognosis. This is the first study depicting a picture of epidemiological characteristics of HPE in China, which can provide useful references for future studies.
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spelling pubmed-65537242019-06-17 Epidemiological characteristics of holoprosencephaly in China, 2007-2014: A retrospective study based on the national birth defects surveillance system Yi, Ling Liu, Zhongqiang Deng, Changfei Li, Xiaohong Wang, Ke Deng, Kui Mu, Yi Zhu, Jun Li, Qi Wang, Yanping Dai, Li PLoS One Research Article OBJECTIVE: To describe the epidemiology of holoprosencephaly (HPE) in China with special reference to prevalence and associated anomalies. METHODS: Data were abstracted from the Chinese Birth Defects Monitoring Network for the period 2007–2014. Birth prevalence of HPE were assessed by birth year, fetal/infant sex, maternal age, and maternal residential area. Poisson regressions were used to calculate the crude and adjusted prevalence ratios (PR) and their 95% confidence intervals, and linear chi-square test was used to explore time trend for the prevalence of HPE. RESULTS: A total of 1222 HPE cases were identified in 13,284,142 births, yielding an overall prevalence of 0.92 per 10,000 births. The annual prevalence of HPE presented an upward trend (P<0.001), from 0.54 per 10,000 births in 2007 to 1.21 per 10,000 births in 2014. Higher prevalence was found in older maternal-age groups (30–34 years, adjusted PR: 1.19, 95% CI: 1.02–1.40; ≥35 years, adjusted PR: 1.53, 95% CI: 1.26–1.86) in comparison with the maternal-age group of 25 to 29 years. Higher prevalence was also found in infants born to mothers resided in urban areas (adjusted PR: 1.23, 95% CI: 1.08–1.39) and female infants (adjusted PR: 1.30, 95% CI: 1.15–1.47). CONCLUSIONS: HPE is an important perinatal health issue because of its poor prognosis. This is the first study depicting a picture of epidemiological characteristics of HPE in China, which can provide useful references for future studies. Public Library of Science 2019-06-06 /pmc/articles/PMC6553724/ /pubmed/31170204 http://dx.doi.org/10.1371/journal.pone.0217835 Text en © 2019 Yi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Yi, Ling
Liu, Zhongqiang
Deng, Changfei
Li, Xiaohong
Wang, Ke
Deng, Kui
Mu, Yi
Zhu, Jun
Li, Qi
Wang, Yanping
Dai, Li
Epidemiological characteristics of holoprosencephaly in China, 2007-2014: A retrospective study based on the national birth defects surveillance system
title Epidemiological characteristics of holoprosencephaly in China, 2007-2014: A retrospective study based on the national birth defects surveillance system
title_full Epidemiological characteristics of holoprosencephaly in China, 2007-2014: A retrospective study based on the national birth defects surveillance system
title_fullStr Epidemiological characteristics of holoprosencephaly in China, 2007-2014: A retrospective study based on the national birth defects surveillance system
title_full_unstemmed Epidemiological characteristics of holoprosencephaly in China, 2007-2014: A retrospective study based on the national birth defects surveillance system
title_short Epidemiological characteristics of holoprosencephaly in China, 2007-2014: A retrospective study based on the national birth defects surveillance system
title_sort epidemiological characteristics of holoprosencephaly in china, 2007-2014: a retrospective study based on the national birth defects surveillance system
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553724/
https://www.ncbi.nlm.nih.gov/pubmed/31170204
http://dx.doi.org/10.1371/journal.pone.0217835
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