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Enhancement of binding avidity by bivalent binding enables PrP(Sc)-specific detection by anti-PrP monoclonal antibody 132

Anti-prion protein (PrP) monoclonal antibody 132, which recognizes mouse PrP amino acids 119–127, enables us to reliably detect abnormal isoform prion protein (PrP(Sc)) in cells or frozen tissue sections by immunofluorescence assay, although treatment with guanidinium salts is a prerequisite. Despit...

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Detalles Bibliográficos
Autores principales:	Suzuki, Akio, Yamasaki, Takeshi, Hasebe, Rie, Horiuchi, Motohiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553756/ https://www.ncbi.nlm.nih.gov/pubmed/31170247 http://dx.doi.org/10.1371/journal.pone.0217944

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