Microdialysis combined with liquid chromatography-tandem mass spectrometry for the quantitation of gemifloxacin and its application to a muscle penetration study in healthy and MRSA-infected rats

Pharmacological efficacy is based on the drug concentration in target tissues, which usually cannot be represented by the plasma concentration. The purpose of this study was to compare the pharmacokinetic characteristics of gemifloxacin in plasma and skeletal muscle and evaluate its tissue penetrati...

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Detalles Bibliográficos
Autores principales: Zhao, Rui, Wang, Qing, Hu, Xin-Xin, Nie, Tong-Ying, Yang, Xin-Yi, Li, Cong-Ran, Lu, Xi, Wang, Xiukun, Jiang, Jian-Dong, Pang, Jing, You, Xue-Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553852/
https://www.ncbi.nlm.nih.gov/pubmed/31170198
http://dx.doi.org/10.1371/journal.pone.0217573

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