Beyond Blood Smears: Qualification of Plasmodium 18S rRNA as a Biomarker for Controlled Human Malaria Infections

18S rRNA is a biomarker that provides an alternative to thick blood smears in controlled human malaria infection (CHMI) trials. We reviewed data from CHMI trials at non-endemic sites that used blood smears and Plasmodium 18S rRNA/rDNA biomarker nucleic acid tests (NATs) for time to positivity. We va...

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Detalles Bibliográficos
Autores principales: Seilie, Annette M., Chang, Ming, Hanron, Amelia E., Billman, Zachary P., Stone, Brad C., Zhou, Kevin, Olsen, Tayla M., Daza, Glenda, Ortega, Jose, Cruz, Kurtis R., Smith, Nahum, Healy, Sara A., Neal, Jillian, Wallis, Carolyn K., Shelton, Lisa, Mankowski, Tracie (VonGoedert), Wong-Madden, Sharon, Mikolajczak, Sebastian A., Vaughan, Ashley M., Kappe, Stefan H. I., Fishbaugher, Matt, Betz, Will, Kennedy, Mark, Hume, Jen C. C., Talley, Angela K., Hoffman, Stephen L., Chakravarty, Sumana, Sim, B. Kim Lee, Richie, Thomas L., Wald, Anna, Plowe, Christopher V., Lyke, Kirsten E., Adams, Matthew, Fahle, Gary A., Cowan, Elliot P., Duffy, Patrick E., Kublin, James G., Murphy, Sean C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553913/
https://www.ncbi.nlm.nih.gov/pubmed/31017084
http://dx.doi.org/10.4269/ajtmh.19-0094

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