Platelet-derived growth factor activates nociceptive neurons by inhibiting M-current and contributes to inflammatory pain

Endogenous inflammatory mediators contribute to the pathogenesis of pain by acting on nociceptors, specialized sensory neurons that detect noxious stimuli. Here, we describe a new factor mediating inflammatory pain. We show that platelet-derived growth factor (PDGF)-BB applied in vitro causes repeti...

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Detalles Bibliográficos
Autores principales: Barkai, Omer, Puig, Stephanie, Lev, Shaya, Title, Ben, Katz, Ben, Eli-Berchoer, Luba, Gutstein, Howard B., Binshtok, Alexander M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553959/
https://www.ncbi.nlm.nih.gov/pubmed/30933959
http://dx.doi.org/10.1097/j.pain.0000000000001523

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