Progression of the role of CRYAB in signaling pathways and cancers

CRYAB is a member of the small heat shock protein family, first discovered in the lens of the eye, and involved in various diseases, such as eye and heart diseases and even cancers, for example, breast cancer, lung cancer, prostate cancer, and ovarian cancer. In addition, CRYAB proteins are involved...

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Autores principales: Zhang, JunFei, Liu, Jia, Wu, JiaLi, Li, WenFeng, Chen, ZhongWei, Yang, LiShan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553995/
https://www.ncbi.nlm.nih.gov/pubmed/31239701
http://dx.doi.org/10.2147/OTT.S201799
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author Zhang, JunFei
Liu, Jia
Wu, JiaLi
Li, WenFeng
Chen, ZhongWei
Yang, LiShan
author_facet Zhang, JunFei
Liu, Jia
Wu, JiaLi
Li, WenFeng
Chen, ZhongWei
Yang, LiShan
author_sort Zhang, JunFei
collection PubMed
description CRYAB is a member of the small heat shock protein family, first discovered in the lens of the eye, and involved in various diseases, such as eye and heart diseases and even cancers, for example, breast cancer, lung cancer, prostate cancer, and ovarian cancer. In addition, CRYAB proteins are involved in a variety of signaling pathways including apoptosis, inflammation, and oxidative stress. This review summarizes the recent progress concerning the role of CRYAB in signaling pathways and diseases. Therefore, the role of CRYAB in signaling pathways and cancers is urgently needed. This article reviews the regulation of CRYAB in the apoptotic inflammatory signaling pathway and its role in cancers progression and as a key role in anti-cancer therapy targeting CRYAB in an effort to improve outcomes for patients with metastatic disease.
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spelling pubmed-65539952019-06-25 Progression of the role of CRYAB in signaling pathways and cancers Zhang, JunFei Liu, Jia Wu, JiaLi Li, WenFeng Chen, ZhongWei Yang, LiShan Onco Targets Ther Review CRYAB is a member of the small heat shock protein family, first discovered in the lens of the eye, and involved in various diseases, such as eye and heart diseases and even cancers, for example, breast cancer, lung cancer, prostate cancer, and ovarian cancer. In addition, CRYAB proteins are involved in a variety of signaling pathways including apoptosis, inflammation, and oxidative stress. This review summarizes the recent progress concerning the role of CRYAB in signaling pathways and diseases. Therefore, the role of CRYAB in signaling pathways and cancers is urgently needed. This article reviews the regulation of CRYAB in the apoptotic inflammatory signaling pathway and its role in cancers progression and as a key role in anti-cancer therapy targeting CRYAB in an effort to improve outcomes for patients with metastatic disease. Dove 2019-05-30 /pmc/articles/PMC6553995/ /pubmed/31239701 http://dx.doi.org/10.2147/OTT.S201799 Text en © 2019 Zhang et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Zhang, JunFei
Liu, Jia
Wu, JiaLi
Li, WenFeng
Chen, ZhongWei
Yang, LiShan
Progression of the role of CRYAB in signaling pathways and cancers
title Progression of the role of CRYAB in signaling pathways and cancers
title_full Progression of the role of CRYAB in signaling pathways and cancers
title_fullStr Progression of the role of CRYAB in signaling pathways and cancers
title_full_unstemmed Progression of the role of CRYAB in signaling pathways and cancers
title_short Progression of the role of CRYAB in signaling pathways and cancers
title_sort progression of the role of cryab in signaling pathways and cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553995/
https://www.ncbi.nlm.nih.gov/pubmed/31239701
http://dx.doi.org/10.2147/OTT.S201799
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